Mettler Toledo XS105DU Dual-Range Semi-Micro Balance – Used & Refurbished
The Mettler Toledo XS105DU Dual-Range Semi-Micro Balance combines high-resolution semi-micro weighing with the flexibility of a conventional analytical balance. Its dual-range weighing system provides 0.01 mg (10 µg) readability through a 41 g fine range and 0.1 mg readability up to its full 120 g capacity, allowing laboratories to perform both small-sample high-resolution measurements and routine analytical weighing on a single instrument.
Available used and refurbished from American Instrument Exchange, the Mettler Toledo XS105DU is well suited for pharmaceutical research, analytical chemistry, standards preparation, formulation, quality control, gravimetric analysis, and other quantitative laboratory applications. Each balance is inspected, cleaned, calibrated, and tested for weighing performance before shipment and includes a 90-day warranty from American Instrument Exchange.
Key Features
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120 g maximum weighing capacity
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41 g high-resolution fine range
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0.01 mg / 10 µg readability in the fine range
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0.1 mg readability through the full range
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FACT automatic internal adjustment
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MonoBloc weighing technology
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SmartGrid weighing pan reduces turbulence in the weighing chamber
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Enclosed draft shield protects sensitive measurements from air movement
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Approximately 3-second settling time
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±0.2 mg linearity
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Large, clear balance display
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Built-in applications for statistics, formulation, density, percent weighing, and piece counting
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RS232 connectivity for compatible computers, printers, and peripherals
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Tool-free removable draft shield components simplify cleaning
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Used, refurbished, calibrated, and tested by American Instrument Exchange
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90-day warranty included
Overview
The Mettler Toledo XS105DU is designed for laboratories that need greater sensitivity than a conventional analytical balance but do not necessarily require a dedicated microbalance.
Its dual-range design provides 10 µg readability through the first 41 g of its weighing range. For larger samples and containers, the balance continues to its full 120 g capacity with conventional analytical readability of 0.1 mg.
This gives the XS105DU considerable versatility.
Small quantities of standards, active ingredients, filters, compounds, and other samples can be measured using the high-resolution fine range, while larger samples can be weighed without transferring the procedure to another balance.
Mettler Toledo combines this dual-range weighing capability with SmartGrid weighing technology, FACT automatic internal adjustment, an enclosed draft shield, and ergonomic sample handling.
For laboratories that routinely move between semi-micro and analytical weighing applications, the XS105DU can potentially perform work that would otherwise require two separate balances.
Common Applications
The Mettler Toledo XS105DU is particularly well suited for procedures involving small samples, high-resolution quantitative measurements, and conventional analytical weighing.
Pharmaceutical and biotechnology laboratories can use the balance for standards preparation, active ingredient weighing, formulation research, reagent preparation, sample preparation, quality control, and other quantitative procedures.
Analytical chemistry laboratories may use the XS105DU for gravimetric analysis, solution preparation, reference-standard preparation, density determination, differential weighing, and other procedures requiring precise measurement of relatively small quantities.
Environmental laboratories can use the balance for filter and particulate weighing, while materials science, academic, and industrial research laboratories can use it for small-sample preparation, comparative weighing, formulation, and experimental work.
The dual-range configuration is particularly valuable in laboratories where some procedures require 10 µg resolution while others can be efficiently completed at conventional 0.1 mg analytical readability.
Ideal Laboratory Types
The XS105DU is a strong choice for pharmaceutical, biotechnology, analytical chemistry, environmental testing, materials science, academic research, formulation, manufacturing, and quality-control laboratories.
It is particularly appropriate for laboratories that need semi-micro sensitivity without giving up the flexibility of a conventional analytical weighing range.
For organizations routinely working with relatively small quantities of expensive compounds, standards, pharmaceutical ingredients, filters, or research samples, the 10 µg fine range can provide an important improvement over standard 0.1 mg analytical balances.
At the same time, its full 120 g capacity allows the XS105DU to remain useful for everyday analytical weighing.
Dual-Range Semi-Micro Weighing Performance
The defining characteristic of the XS105DU is its dual-range weighing system.
Within the fine range, the balance provides:
41 g maximum fine-range capacity with 0.01 mg / 10 µg readability.
For larger samples, it provides:
120 g maximum capacity with 0.1 mg readability.
This configuration allows users to take advantage of semi-micro resolution when it is actually required without sacrificing the larger capacity needed for more conventional analytical procedures.
Mettler Toledo specifies ±0.2 mg linearity and an approximately 3-second settling time for the XS105DU.
The SmartGrid weighing pan further supports efficient stabilization by reducing turbulence inside the weighing chamber. Combined with the enclosed draft shield, this helps protect high-resolution measurements from air movement and other environmental disturbances.
Minimum Sample Weight & USP Applications
Minimum sample weight becomes particularly important when a dual-range balance is used for small-sample pharmaceutical or other regulated applications.
The ability of the XS105DU to display measurements at 0.01 mg readability does not mean that a 0.01 mg sample can be weighed quantitatively with acceptable uncertainty.
Minimum weight depends primarily on repeatability, installed balance performance, environmental conditions, and the laboratory's allowable measurement uncertainty.
Because the XS105DU operates at two different resolution levels, laboratories should establish minimum weight based on the specific weighing range and application being used.
For USP, GMP, GLP, or other regulated procedures, minimum sample weight should therefore be established and documented according to the performance of the individual installed balance and the laboratory's qualification procedures.
This is especially important when the XS105DU is being selected specifically to reduce sample quantities compared with a conventional analytical balance.
Controlling Drafts, Vibration & Static
Environmental influences become increasingly important when weighing at 10 µg resolution.
Air currents, vibration, temperature changes, static electricity, improper leveling, and operator technique can all produce measurable effects on semi-micro weighing results.
The XS105DU uses an enclosed draft shield to isolate the weighing chamber from room air movement. Mettler Toledo's SmartGrid weighing pan further reduces turbulence by minimizing the amount of solid pan surface exposed to moving air.
Static electricity should also be considered when weighing powders, filters, plastic containers, glassware, and other materials capable of accumulating electrical charge. Electrostatic forces can create apparent changes in mass that become significant at semi-micro resolution.
For best performance, the XS105DU should be installed on a rigid, level, vibration-resistant surface away from HVAC vents, frequently opened doors, direct sunlight, centrifuges, shakers, refrigeration compressors, and other sources of environmental disturbance.
A dedicated balance table or anti-vibration workstation may be particularly beneficial when the instrument is routinely used within its 10 µg fine range.
Calibration & Internal Adjustment
The Mettler Toledo XS105DU incorporates FACT automatic internal adjustment.
FACT helps maintain weighing performance as environmental conditions change by allowing the balance to perform internal adjustment automatically.
This is particularly useful for semi-micro measurements, where temperature-related changes that may be insignificant on a lower-resolution balance can become measurable.
Automatic internal adjustment should still be considered one part of a complete balance quality program.
Laboratories operating under GLP, GMP, USP, or internal quality systems may require scheduled external performance verification using appropriate traceable weights along with documented accuracy, repeatability, linearity, and minimum-weight testing.
American Instrument Exchange calibrates and evaluates refurbished balances before shipment to confirm reliable weighing performance.
SmartGrid & Sample Handling
The XS105DU uses Mettler Toledo's SmartGrid weighing pan, which was developed specifically to improve analytical and semi-micro weighing performance.
Instead of a conventional solid pan, SmartGrid uses an open-grid design that presents less surface area to moving air. This reduces turbulence inside the draft shield and can help the weighing system stabilize more efficiently.
The design also makes it possible to use specialized sample holders for different containers and weighing vessels.
Direct weighing into the final sample container can reduce transfers and minimize material loss, particularly when working with small quantities of expensive compounds, pharmaceutical ingredients, standards, or research materials.
The XS-series draft shield can also be disassembled without specialized tools, providing easier access to the weighing chamber for routine cleaning.
Built-In Applications & Data Connectivity
The Mettler Toledo XS105DU provides built-in applications that extend its capabilities beyond straightforward mass determination.
Available functions include statistics, formulation, density determination, percent weighing, piece counting, and routine weighing, allowing the instrument to support a variety of analytical and sample-preparation procedures.
The balance also provides an RS232 data interface, allowing compatible computers, printers, and other laboratory peripherals to be connected.
Electronic data transfer can reduce manual transcription and make it easier to incorporate weighing results into standardized laboratory procedures.
Key Specifications
| Specification |
Mettler Toledo XS105DU |
| Balance Type |
Dual-Range Semi-Micro / Analytical Balance |
| Maximum Capacity |
120 g |
| Fine-Range Capacity |
41 g |
| Readability – Fine Range |
0.01 mg / 10 µg |
| Readability – Full Range |
0.1 mg |
| Linearity |
±0.2 mg |
| Settling Time |
Approx. 3 seconds |
| Adjustment |
Internal / automatic FACT |
| Weighing Pan |
78 × 73 mm |
| Weighing Pan Technology |
SmartGrid |
| Draft Protection |
Enclosed draft shield |
| Weighing Technology |
MonoBloc |
| Overall Dimensions |
263 mm W × 453 mm D × 322 mm H |
| Usable Draft Shield Height |
Approx. 235 mm |
| Weight |
Approx. 9.1 kg |
| Connectivity |
RS232 |
| Built-In Applications |
Weighing, statistics, formulation, density, percent weighing, piece counting |
| Fine-Range Technology |
Dual-range weighing |
Choosing Between a Semi-Micro and Analytical Balance
A conventional analytical balance typically provides 0.1 mg readability, which is sufficient for many routine quantitative laboratory procedures.
A semi-micro balance provides finer resolution, commonly reaching 0.01 mg or 10 µg, allowing smaller mass differences to be measured.
The XS105DU effectively combines both capabilities.
When greater sensitivity is needed, its 41 g fine range provides 10 µg readability. When the sample or container exceeds that range, the balance can continue weighing up to 120 g at conventional 0.1 mg analytical resolution.
This makes the XS105DU particularly attractive for laboratories that perform a mixture of small-sample high-resolution work and routine analytical weighing.
For laboratories that require 10 µg readability throughout the entire 120 g range, a single-range high-resolution model such as the XS105 may be preferable. For procedures requiring true 1 µg readability, a dedicated microbalance is generally more appropriate.
XS105DU vs. XS105
Although the Mettler Toledo XS105DU and XS105 share the same 120 g maximum capacity, their weighing systems are configured differently.
The XS105 is a single-range high-resolution analytical balance providing 0.01 mg readability throughout its 120 g weighing range.
The XS105DU instead provides 0.01 mg readability through a 41 g fine range and 0.1 mg readability from there to its full 120 g capacity.
The XS105 therefore provides greater resolution across the entire weighing range.
The XS105DU, however, can be an excellent choice when semi-micro resolution is primarily needed for smaller samples and conventional analytical readability is sufficient for larger loads.
Understanding this distinction is important when comparing the two models, because their identical 120 g maximum capacities do not mean they provide identical weighing performance.
Refurbishment & Performance Testing
Every used Mettler Toledo XS105DU sold by American Instrument Exchange is inspected, cleaned, refurbished as necessary, calibrated, and tested before shipment.
Because this is a dual-range semi-micro balance, testing must verify reliable performance not only across the full 120 g range but also within the 41 g high-resolution fine range.
Our technicians use appropriate calibration weights to evaluate critical weighing characteristics including accuracy, repeatability, linearity, corner-load tolerances, stability, and reduced span at or near full capacity.
The FACT internal adjustment system, weighing cell, SmartGrid pan, draft shield, display, controls, leveling components, interfaces, and other installed functions are also inspected and tested for proper operation.
The weighing chamber and accessible components are thoroughly cleaned before shipment.
Each refurbished XS105DU includes a 90-day warranty from American Instrument Exchange.
Shipping & Installation Considerations
A semi-micro balance capable of resolving 10 µg changes in mass requires careful transportation and installation.
American Instrument Exchange securely prepares the XS105DU for shipment to protect its weighing system, SmartGrid pan, draft shield, display, and other components.
Once received, the balance should be installed on a rigid, level, vibration-resistant work surface in an area with stable temperature and minimal air movement.
The instrument should be allowed to acclimate to the laboratory environment before final adjustment, verification, and critical weighing procedures are performed.
Laboratories intending to make extensive use of the 10 µg fine range should consider a dedicated balance bench or anti-vibration workstation.
For regulated applications, installation should be followed by appropriate calibration, verification, minimum-weight determination, or qualification according to the laboratory's quality system.
Related Laboratory Equipment
American Instrument Exchange maintains an extensive inventory of used and refurbished laboratory balances, including analytical balances, semi-micro balances, microbalances, and precision balances for applications ranging from routine sample preparation to high-resolution quantitative analysis.
Labs developing complete analytical or sample-preparation workflows can also source centrifuges, water baths, incubators, laboratory refrigerators, laboratory freezers, and other refurbished laboratory equipment from American Instrument Exchange.
Mettler Toledo XS105DU Semi-Micro Balance FAQs
What is the maximum capacity of the Mettler Toledo XS105DU?
The XS105DU has a maximum capacity of 120 g. Its high-resolution fine range extends to 41 g.
What is the readability of the XS105DU?
Within the 41 g fine range, the XS105DU provides 0.01 mg, or 10 µg, readability. Across the remainder of its 120 g capacity, readability is 0.1 mg.
Is the XS105DU a semi-micro balance?
Yes. The XS105DU is appropriately described as a dual-range semi-micro balance because its fine range provides 0.01 mg, or 10 µg, readability.
What is the difference between the XS105DU and XS105?
The XS105 provides 0.01 mg readability throughout its 120 g range. The XS105DU provides 0.01 mg readability through a 41 g fine range and 0.1 mg readability up to 120 g.
Does the XS105DU have automatic internal calibration?
Yes. The XS105DU incorporates FACT automatic internal adjustment, helping maintain weighing performance as environmental conditions change.
What is SmartGrid?
SmartGrid is Mettler Toledo's open-grid weighing pan design. It reduces the influence of turbulence inside the weighing chamber, helping high-resolution measurements stabilize efficiently.
Is the XS105DU suitable for pharmaceutical applications?
Yes. Its semi-micro resolution makes it useful for standards preparation, formulation, small-sample weighing, reagent preparation, quality control, and other pharmaceutical laboratory procedures. Laboratories performing regulated measurements should establish minimum weight and qualification requirements for the individual installed balance.
Can the XS105DU connect to laboratory data systems?
The XS105DU includes RS232 connectivity, allowing compatible printers, computers, and other peripherals to communicate with the balance.
Does American Instrument Exchange test the 10 µg fine range?
Yes. Because the high-resolution fine range is one of the defining capabilities of the XS105DU, American Instrument Exchange evaluates the balance's accuracy, repeatability, stability, and other weighing characteristics using appropriate calibration weights before shipment.
Why purchase a refurbished Mettler Toledo XS105DU?
A refurbished XS105DU provides laboratories with 10 µg semi-micro resolution, 120 g total capacity, FACT automatic internal adjustment, SmartGrid weighing technology, and dual-range flexibility without the acquisition cost associated with comparable new high-resolution balances. American Instrument Exchange tests, calibrates, cleans, and refurbishes each balance before shipment and provides a 90-day warranty.
