There are certain research applications where a conventional laboratory centrifuge simply cannot produce the centrifugal force required to separate the particles of interest. Whether isolating exosomes, purifying viral vectors, separating lipoproteins, harvesting membrane fractions, or performing density gradient ultracentrifugation, these workflows demand an instrument capable of generating hundreds of thousands of times the force of gravity while maintaining exceptional temperature stability and rotor precision.
The Beckman Coulter Optima XE-100 Preparative Ultracentrifuge was engineered specifically for these demanding applications. Capable of reaching 100,000 RPM and generating up to 802,000 × g, the Optima XE-100 is trusted by molecular biology, virology, structural biology, proteomics, pharmaceutical, and biotechnology laboratories performing advanced sample preparation and purification. Rather than simply spinning samples faster, the XE-100 enables researchers to isolate biological particles that are impossible to separate using conventional refrigerated centrifuges.
At American Instrument Exchange, every Beckman ultracentrifuge is thoroughly inspected and tested before shipment. Our technicians verify motor performance, vacuum integrity, refrigeration operation, chamber condition, safety systems, and controller functionality to ensure dependable operation. American Instrument Exchange offers professionally refurbished laboratory centrifuges ranging from benchtop microcentrifuges to high-speed floor models and preparative ultracentrifuges from Beckman Coulter, Thermo Scientific, Eppendorf, and other leading manufacturers.
Features of the Beckman Coulter Optima XE-100
Maximum speed: 100,000 RPM
Maximum centrifugal force: 802,000 × g
Maximum rotor capacity: 1.5 liters
Large 15-inch color touchscreen interface
Thermoelectric refrigeration system (CFC-free)
Regenerative braking system for improved energy efficiency
Compatible with Beckman fixed-angle, swinging bucket, vertical, near-vertical, and continuous-flow rotors
Advanced rotor recognition and integrated safety monitoring
Designed for molecular biology, virology, structural biology, proteomics, and pharmaceutical research
90-day warranty included from American Instrument Exchange
Refurbished and tested by American Instrument Exchange
The Optima XE-100 combines exceptional ultracentrifugation performance with a modern user interface and advanced safety systems, making it one of Beckman's premier preparative ultracentrifuge platforms.
Why Researchers Choose the Beckman Coulter Optima XE-100
The Optima XE-100 is more than a high-speed centrifuge—it's a research platform built for laboratories working at the molecular and cellular level. Applications such as viral vector purification, extracellular vesicle isolation, ribosome preparation, density gradient centrifugation, and protein complex purification require precise speed control, excellent temperature regulation, and rotor stability throughout extended runs.
One reason the XE-100 remains highly desirable in both academic and pharmaceutical laboratories is its compatibility with Beckman's extensive rotor ecosystem. Laboratories can configure the instrument for a wide variety of experimental protocols simply by selecting the appropriate rotor, eliminating the need for multiple specialized centrifuges.
Beckman Coulter Optima XE-100 Common Research Applications
The Beckman Optima XE-100 is routinely used for:
Exosome and extracellular vesicle isolation
Viral vector purification
Density gradient ultracentrifugation
Lipoprotein separation
Ribosome isolation
Protein complex purification
Plasmid DNA preparation
Membrane fraction isolation
Organelle purification
Vaccine development
Structural biology research
Biopharmaceutical process development
Unlike conventional refrigerated centrifuges, preparative ultracentrifuges generate the extreme centrifugal forces necessary to separate viruses, nucleic acids, protein complexes, and other microscopic particles that remain suspended during standard centrifugation.
Beckman Coulter Optima XE-100 Rotor Compatibility and Included Accessories
Rotor flexibility is one of the defining strengths of the Optima XE-100.
Compatible rotor families include:
Fixed-angle rotors
Swinging bucket rotors
Vertical rotors
Near-vertical rotors
Continuous-flow rotors
Zonal rotors
These rotor configurations allow researchers to optimize sedimentation efficiency for a wide variety of biological samples while supporting both analytical and preparative workflows.
Customers should verify included rotors prior to purchase, as ultracentrifuge configurations can vary between systems.
Beckman Coulter Optima XE-100 Specifications
Specification
Details
Manufacturer
Beckman Coulter
Model
Optima XE-100
Condition
Refurbished
Instrument Type
Preparative Ultracentrifuge
Maximum Speed
100,000 RPM
Maximum RCF
802,000 × g
Maximum Rotor Capacity
1.5 Liters
Temperature Range
0°C to 40°C
Cooling System
Thermoelectric
Rotor Compatibility
Beckman Preparative Ultracentrifuge Rotors
Electrical Requirements
200–240V, 30A
Included Rotor
Verify with American Instrument Exchange
Specifications compiled from Beckman Coulter manufacturer literature, technical documentation, and American Instrument Exchange product information.
Power Requirements and Shipping Considerations
The Optima XE-100 is a floor model ultracentrifuge that ships via palletized freight. Laboratories should verify electrical service, floor loading capacity, doorway clearances, and installation requirements before delivery.
American Instrument Exchange can assist with shipping coordination and installation planning to help ensure your ultracentrifuge arrives safely and is ready for operation.
Refurbished Centrifuges from American Instrument Exchange
American Instrument Exchange specializes in professionally refurbished laboratory centrifuges including ultracentrifuges, refrigerated floor model centrifuges, benchtop centrifuges, microcentrifuges, vacuum concentrators, and bioprocessing centrifuges.
Our technicians inspect and test every instrument for:
Vacuum system integrity
Refrigeration performance
Motor operation
Rotor functionality
Controller performance
Overall operational reliability
If the ultracentrifuge is sold with a rotor, we also verify rotor compatibility and operational performance before shipment.
Many laboratories purchasing an ultracentrifuge are also outfitting an entire research facility. American Instrument Exchange also offers professionally refurbished laboratory freezers and ultra-low freezers, laboratory incubators, and biosafety cabinets, allowing customers to source multiple pieces of laboratory equipment from a single trusted supplier.
Beckman Coulter Optima XE-100 Service and Support
American Instrument Exchange and AIE Laboratory Services provide diagnostics, preventative maintenance, depot repair, and service for Beckman ultracentrifuges and many other laboratory instruments.
Our service team also supports refrigerated centrifuges, laboratory freezers, ultra-low freezers, incubators, and biosafety cabinets to help laboratories maximize equipment uptime.
Why would a laboratory purchase an ultracentrifuge instead of a conventional refrigerated centrifuge?
Preparative ultracentrifuges generate dramatically higher centrifugal forces, allowing researchers to isolate viruses, exosomes, lipoproteins, ribosomes, and other microscopic particles that cannot be effectively separated using standard laboratory centrifuges.
What types of research commonly use the Optima XE-100?
The Optima XE-100 is widely used in molecular biology, virology, structural biology, proteomics, vaccine development, lipid research, and biopharmaceutical process development.
Does this ultracentrifuge include a rotor?
Rotor availability varies by inventory. Please contact American Instrument Exchange to confirm which rotor, if any, is included with this specific instrument.
What makes the Optima XE-100 different from earlier Beckman ultracentrifuges?
The XE-100 combines modern touchscreen controls, advanced safety monitoring, regenerative braking, and Beckman's extensive rotor compatibility into a platform that remains highly capable for today's research laboratories.
Is a refurbished Beckman Optima XE-100 a good investment?
For laboratories requiring preparative ultracentrifugation, a professionally refurbished Optima XE-100 provides research-grade performance at a fraction of the cost of a comparable new system while preserving compatibility with Beckman's extensive rotor family.
Can American Instrument Exchange service Beckman ultracentrifuges?
Yes. AIE Laboratory Services provides diagnostics, preventative maintenance, and repair support for many Beckman Coulter centrifuge platforms, including the Optima ultracentrifuge series.
Testing Procedures for Used and Refurbished Laboratory Centrifuges
Ensure Quality, Accuracy, and Compliance Before Deployment
Used and refurbished laboratory centrifuges from American Instrument Exchange undergo testing procedures to ensure they meet the performance, safety, and compliance standards required in modern laboratories.
Why Testing Used Laboratory Centrifuges Is Essential
Before a centrifuge is reintroduced into a lab environment, it must be tested for:
Mechanical integrity
Rotor balance and speed accuracy
Safety system functionality
Electrical compliance
Proper testing helps extend equipment lifespan, reduce downtime, and ensure safety in high-stakes lab environments such as clinical diagnostics, biotechnology, and research applications.
Our structured testing protocol for used and refurbished centrifuges ensures equipment safety, accuracy, and longevity.
Key Testing Procedures for Refurbished and Used Centrifuges
1. Initial Visual Inspection
Check for signs of wear, corrosion, or damage to housing, lid, and control panels
Inspect power cords, plugs, and connectors for fraying or exposed wiring
Confirm that the rotor and accessories are compatible and undamaged
2. Functional Testing
Power up the centrifuge and confirm successful boot-up of digital or analog displays
Test lid lock and emergency stop mechanisms
Run initial cycles at various speeds to check for abnormal noise or vibration
3. Rotor and Speed Verification
Test all programmable speed settings to confirm consistent acceleration and deceleration
Monitor temperature, vibration, and RPM consistency throughout the cycle
Balance testing ensures smooth operation and prevents wear on internal components
4. Electrical Safety and Grounding Tests
Verify that all electrical components are properly grounded and shielded
5. Temperature Control (if applicable)
For refrigerated centrifuges, test cooling function to ensure temperature stability within set ranges
Check refrigerant levels and inspect for compressor noise or failure
6. Final Quality Assurance Checklist
Conduct a full run-through using the user interface
Document all test results
Repair and Refurbishment Protocol for Used Laboratory Centrifuges
Certified Quality from American Instrument Exchange
At American Instrument Exchange, we follow a meticulous repair and refurbishment protocol to ensure that every used laboratory centrifuge we sell. We strive for reliable performance and long-term durability—providing labs with exceptional value on high-quality pre-owned centrifuges.
Why Choose a Refurbished Centrifuge from American Instrument Exchange?
Fully tested
Backed by warranty and performance guarantee
Cost-effective alternative to new lab equipment
Environmentally responsible through equipment reuse
Supported by expert technicians with decades of experience
Step-by-Step Refurbishment Protocol
Every used centrifuge at American Instrument Exchange goes through the following comprehensive repair and refurbishment process:
1. Initial Intake & Inspection
Our technicians perform a complete visual and mechanical inspection
Evaluation of hinges, seals, gaskets, and electrical components
Any physical damage, missing parts, or wear is documented for repair
2. Cleaning and decontamination
Full internal and external cleaning using non-abrasive, disinfectant-safe products
Biological or chemical residue is decontaminated/cleaned
3. Mechanical & Electrical Repairs
Damaged or worn parts (e.g., drive motors, lid latches, rotor buckets) are replaced or repaired
Electrical components, sensors, and fuses are tested and replaced as needed
Wiring is inspected for integrity and safety per industry standards
4. Rotor & Accessory Evaluation
All rotors, buckets, and adapters are inspected for cracks, corrosion, and balance
Non-conforming components are replaced with OEM or equivalent alternatives
5. Performance Testing
Rotor speed (RPM), acceleration, and deceleration are verified
Refrigerated centrifuges undergo temperature stability testing across set ranges
6. Safety System Verification
Lid lock and interlock systems are tested for proper function
Emergency stop and imbalance detection systems are verified
Electrical safety and grounding tests are conducted
Trust the Experts at American Instrument Exchange
With over 50 years of experience in the industry, American Instrument Exchange is a trusted name for refurbished lab equipment. Our centrifuge refurbishment protocol reflects our commitment to quality, safety, and customer satisfaction.
Warranty Information
All used equipment sold by American Instrument Exchange is refurbished/reconditioned, tested to meet specifications, cleaned, and comes with a 90-day warranty from the date of shipment unless otherwise specified. New products include a warranty from the manufacturer. Your warranty is only valid if you have paid your invoice. If your invoice is over 30 days old, warranty work will not be performed until your invoice is paid in full. American Instrument Exchange is not liable for any special or consequential damages that result from the use of, or the inability to use, the materials on this site or the performance of the products,
Exceptions include international sales and items that are agreed to be sold with a lesser warranty or items that are agreed to be sold “as is.”
Should there be visible shipping damage to packaging or concealed shipping damage to item(s) supplied, buyer must communicate such damage to the delivering entity or carrier upon receipt first and to American Instrument the same day item is accepted / signed for. Failure to do so voids warranty. Customer decision to involve / procure third party or OEM service other than American Instrument or AIE assigned vendors to resolve in-warranty instrument failure or defect without first placing a service call to American Instrument voids warranty.
Return & Cancellation Policy
American Instrument Exchange will authorize the return of and issue a full refund for any equipment that is not working as represented and could not be replaced or repaired to the customer’s satisfaction by AIE or a representative of AIE during the warranty period. Returns without prior authorization and an RMA number will not be accepted.
Customers are responsible for proper packaging of the equipment and all included accessories. American Instrument will pay for insurance and shipping costs. Non-inventory items bought specifically to fill customer orders may possibly be returned, but on a case by case basis.
Customers who cancel orders after refurbishing has begun or after delivery where there are no equipment performance issues may be subject to a Restocking/Cancellation Fee of 20% or more and responsible for shipping costs for both the delivery and return.
Ongoing and Extended Support Options
American Instrument Exchange is able to provide additional repair and support services outside the warranty terms for most products that sell.
For biosafety cabinets, clean benches, chemical fume hoods, and other clean air products our team at AIE Laboratory Services can provide certifications, repairs, decontaminations, and other services for customers throughout New England, and guidance and limited technical assistance for any customers in the US and Canada for new or refurbished biosafety cabinets purchased from American Instrument Exchange.
For all other products, the repair service team at American Instrument Exchange can provide both field and depot repair evaluations. We can easily schedule and coordinate the pick-up and transportation of your malfunctioning equipment. By offering hourly rates lower than most OEM service providers and eliminating travel time for technicians, we help reduce repair costs. Furthermore, our lab depot repair service minimizes or eliminates scheduling delays. Our experienced service technicians are qualified to restore your equipment to factory specifications.
Yes, all equipment from American Instrument Exchange comes with a warranty. Used/reconditioned/refurbished equipment is tested to make sure it operates to the manufacturer's specifications and comes with a 90-day warranty (unless otherwise noted). New equipment comes with a warranty from the manufacturer.
How do you test and recondition the equipment?
Testing requirements vary across all the equipment categories we sell. Temperature controlled units are tested with NIST traceable probes and data loggers. Gaskets, external housing, glass, handles, controls and control screens are all thoroughly inspected for integrity and functionality. We test all equipment using the manufacturer's parameters and specifications to confirm that the unit operates properly.
How do products ship from American Instrument Exchange?
We can ship products both nationally and internationally using a well-established network of transporters. Smaller items will ship via UPS. Larger equipment will be palletized and shipped either LTL or air-ride, depending on the specific equipment and/or delivery requirements.
Return and order cancellation policy
American Instrument Exchange will accept the return of any product that is not working as represented and could not be replaced or repaired to the customer's satisfaction during the warranty period. Customers who cancel orders after refurbishing has begun will be subject to a cancellation and restocking fee of between 20% and 40%.
Are discounts available for educational or non-profit institutions, or for bulk purchases?
Yes – call or email us today with a list of equipment you're looking for and we can potentially put together a quote that includes a discount.
How does your price matching policy work?
We strive to keep our pricing competitive and reasonable. If you find comparable items for sale at a lower price from other vendors please send us a link and or quote for the item and we'll do our best to match or beat the price.
Can I see the equipment in person before committing to a purchase?
Customers are welcome to make an appointment to view equipment in our warehouse. Given our workload we may not be able to test or clean the equipment prior to your arrival if you have not committed to an order.
1023 Western Avenue is a working warehouse, not a showroom, and customers should dress appropriately and wear closed toe shoes.
Can I ship products that I purchased elsewhere to American Instrument for repair?
Yes – please see our repair services page for more information.
