Coy Laboratory InVitro Hypoxic Cabinet System
Shipping
All products ship from our 30,000 sq. ft. Haverhill, MA warehouse
Shipping
All products ship from our 30,000 sq. ft. Haverhill, MA warehouse
The Coy Laboratory InVitro Hypoxic Cabinet System is a compact, hermetically sealed controlled-oxygen chamber designed for cell culture, hypoxia research, physiological oxygen studies, cancer biology, stem cell research, and other applications requiring precisely controlled oxygen conditions. Unlike a full-size hypoxia glove box workstation, the Coy InVitro Cabinet is designed to operate inside an existing laboratory incubator, allowing the incubator to provide temperature control while the sealed Coy chamber independently controls its internal gas environment.
This particular American Instrument Exchange system includes a Coy SP2 oxygen controller and sensor along with an AC100 CO₂ controller. This configuration allows researchers to establish controlled oxygen and carbon dioxide conditions within the chamber rather than relying solely on premixed gas.
The Coy InVitro design is especially useful for researchers who need controlled oxygen during incubation but do not require the ability to continuously manipulate cultures inside a glove-box workspace. Its hermetically sealed construction allows the controller to adjust chamber atmosphere through intermittent gas purges rather than continuously flowing large quantities of gas through the system. This can reduce gas consumption while providing stable, repeatable oxygen conditions.
Oxygen can be adjusted in 0.1% increments across a broad control range, while the installed CO₂ control system provides independent adjustment of carbon dioxide up to 20%. An internal circulation fan helps maintain a uniform chamber atmosphere, while a humidification tray can add moisture for cell-culture applications.
This Coy Laboratory InVitro Hypoxic Cabinet System is used and refurbished by American Instrument Exchange. AIE technicians inspect and test the chamber, controllers, sensors, seals, circulation system, gas connections, and other installed components before shipment. The system includes a 90-day warranty.
Coy Laboratory InVitro Hypoxic Cabinet System
Compact hermetically sealed hypoxia chamber
Designed to operate inside an existing laboratory incubator
SP2 oxygen controller and O₂ sensor included
AC100 CO₂ controller included
Oxygen adjustment in 0.1% increments
CO₂ control from 0–20% in 0.1% increments
Microprocessor-controlled gas purging
Internal circulation fan
Pressure relief valve
Two sensor ports
Gas inlet
Pullout sliding shelf
Humidification tray
Adjustable leveling pads
Approximate dimensions of this AIE unit: 14"W × 16"D × 15"H
Used and refurbished by American Instrument Exchange
90-day warranty included
Oxygen concentration is an important experimental variable in cell culture.
Although atmospheric air contains approximately 21% oxygen, cells within living tissues frequently experience substantially lower oxygen concentrations. Cancer cells, stem cells, primary cells, and other biological systems can change their metabolism, signaling, gene expression, proliferation, differentiation, and response to therapeutics as oxygen availability changes.
The Coy InVitro Hypoxic Cabinet gives researchers a way to establish controlled oxygen conditions without purchasing a full-size hypoxia workstation.
The sealed cabinet is placed inside a compatible laboratory incubator. The incubator controls temperature, while the Coy system establishes the desired gas environment inside the chamber.
This division of functions makes the system compact, efficient, and particularly attractive for laboratories that already have suitable incubator capacity.
The Coy InVitro Hypoxic Cabinet can support hypoxia research, physiological oxygen cell culture, cancer biology, tumor-cell studies, stem cell research, primary cell culture, metabolic research, ischemia studies, cardiovascular research, drug discovery, developmental biology, tissue engineering, regenerative medicine, spheroid culture, organoid research, and other experiments involving controlled oxygen conditions.
Its independently controlled CO₂ capability also makes this particular configuration especially useful for mammalian cell culture applications requiring both reduced oxygen and controlled carbon dioxide.
The Coy InVitro Hypoxic Cabinet is well suited to biotechnology companies, pharmaceutical research laboratories, cancer research programs, stem cell laboratories, academic research institutions, medical schools, translational research laboratories, regenerative medicine programs, tissue-engineering laboratories, drug-discovery groups, and other facilities conducting oxygen-sensitive cell culture experiments.
It is particularly attractive for laboratories that already own a suitable incubator and want to add controlled-oxygen capability without dedicating floor or bench space to a much larger hypoxia workstation.
| Specification | Details |
|---|---|
| Manufacturer | Coy Laboratory Products |
| Product | InVitro Hypoxic Cabinet System |
| AIE Inventory Number | 2730C |
| Equipment Type | Controlled-Oxygen Cell Culture Cabinet |
| Primary Application | InVitro Hypoxia Research |
| Chamber Construction | Hermetically Sealed |
| Oxygen Controller | Coy SP2 |
| Oxygen Sensor | Included |
| O₂ Adjustment | 0.1% Increments |
| O₂ Control Capability | Broad Hypoxic-to-Atmospheric / Elevated Range |
| CO₂ Controller | Coy AC100 |
| CO₂ Range | 0–20% |
| CO₂ Adjustment | 0.1% Increments |
| Temperature Control | Supplied by Compatible External Incubator |
| Internal Circulation | Fan |
| Humidification | Water / Humidification Tray |
| Pressure Protection | Pressure Relief Valve |
| Sensor Ports | Two |
| Gas Inlet | Included |
| Shelf | Pullout Sliding Shelf |
| Approx. Dimensions | 14"W × 16"D × 15"H |
| Leveling | Adjustable Pads |
| Condition | Used / Refurbished |
| Warranty | 90 Days from American Instrument Exchange |
The primary purpose of the Coy InVitro Cabinet is to make oxygen concentration a controlled experimental parameter.
Rather than exposing cells to atmospheric oxygen by default, researchers can establish an oxygen concentration appropriate to the experimental model.
The SP2 controller monitors oxygen through its sensor and adds the appropriate gas when chamber conditions move away from the selected setpoint.
This automated feedback approach provides substantially greater experimental control than manually flushing a container with nitrogen and estimating the resulting oxygen concentration.
Coy's hypoxic cabinet control system allows oxygen levels to be adjusted in increments of 0.1%.
This provides the flexibility needed to investigate both pronounced hypoxia and more moderate physiological oxygen conditions.
Researchers can therefore compare cellular behavior across multiple oxygen environments rather than treating oxygen as simply an on/off experimental condition.
The appropriate oxygen setpoint depends on the cell type, tissue model, research question, and experimental protocol.
This particular AIE system includes a Coy AC100 CO₂ controller rather than relying only on premixed nitrogen/CO₂ gas.
CO₂ can be controlled from 0–20% in 0.1% increments.
This is particularly useful for mammalian cell culture because bicarbonate-buffered culture media rely on controlled carbon dioxide to maintain appropriate pH.
Independent CO₂ control also gives researchers greater flexibility when oxygen setpoints change.
Oxygen and carbon dioxide serve different functions in cell culture.
Oxygen may be deliberately reduced to simulate hypoxic or physiologically relevant conditions, while CO₂ is commonly maintained at a level appropriate for the culture medium's buffering system.
Having dedicated O₂ and CO₂ controllers allows these two variables to be managed independently.
This makes the AIE configuration more versatile than a simple cabinet operated exclusively with a fixed premixed gas cylinder.
One of the most important characteristics of the Coy InVitro system is its hermetically sealed construction.
A well-sealed chamber minimizes exchange between the controlled internal atmosphere and surrounding incubator air.
Because the atmosphere is retained rather than continuously escaping, the controller does not need to maintain a constant high-volume gas purge.
This contributes to both environmental stability and lower gas consumption.
Coy's control approach is based on sensor feedback and intermittent gas addition.
The microprocessor monitors chamber oxygen and initiates a gas purge when conditions need correction.
Once the desired setpoint is reached, continuous gas flow is unnecessary.
This differs from systems that rely on a continuous purge to maintain hypoxia.
For laboratories conducting frequent or long-duration experiments, reduced gas consumption can lower operating costs and reduce cylinder-change frequency.
The Coy InVitro Cabinet does not incorporate its own full temperature-control system.
Instead, the complete sealed cabinet is placed inside a compatible laboratory incubator.
The surrounding incubator establishes the desired temperature, while the Coy chamber controls the gas environment around the samples.
This arrangement makes efficient use of equipment many cell-culture laboratories already own.
It also helps keep the hypoxia system compact.
Because the cabinet is intended to operate inside an incubator, internal incubator dimensions should be checked carefully before purchase.
This particular AIE cabinet measures approximately 14 inches wide × 16 inches deep × 15 inches high.
The incubator must provide sufficient clearance around the chamber for installation, gas tubing, circulation, and access.
Shelf position and weight capacity should also be considered.
An internal circulation fan helps distribute the controlled atmosphere throughout the cabinet.
Without circulation, localized differences in oxygen and CO₂ could potentially develop around shelves, culture vessels, or gas-inlet locations.
Mixing the internal atmosphere helps the sensor obtain a more representative reading and promotes more consistent conditions around the cultures.
Samples should still be positioned so they do not unnecessarily obstruct airflow.
The cabinet includes a humidification tray that can hold water to increase moisture within the sealed chamber.
Humidity is particularly important during cell culture because dry environments can increase evaporation from culture vessels and alter media concentration or osmolality.
The tray provides a straightforward passive method for adding moisture to the chamber.
Humidity should be managed according to the experimental protocol and care should be taken to avoid excessive condensation.
A pullout sliding shelf provides convenient access to culture vessels and samples.
The shelf allows researchers to organize dishes, plates, flasks, or other experimental materials within the relatively compact chamber.
Shelf arrangement can also make it easier to perform short-duration transfers when samples need to be removed for analysis.
Changes in temperature or gas addition can create small pressure changes inside a sealed chamber.
The integrated pressure relief valve helps protect the chamber from excessive positive pressure.
This feature allows the cabinet to remain tightly sealed while accommodating the small volume changes associated with gas-control operation.
Two sensor ports provide access for environmental monitoring.
These ports support the oxygen and CO₂ control architecture and may facilitate appropriate sensor placement.
Sensor location and calibration are important because the control system relies on accurate environmental measurements to determine when gas should be added.
Hypoxia can influence a wide range of cellular processes, including metabolism, gene expression, signaling pathways, angiogenesis, oxidative stress, proliferation, differentiation, and apoptosis.
The Coy InVitro Cabinet allows researchers to establish reproducible reduced-oxygen conditions rather than relying on uncontrolled exposure to atmospheric oxygen.
This makes it useful across cancer biology, cardiovascular research, developmental biology, stem cell research, and other fields.
Not every controlled-oxygen experiment involves severe hypoxia.
Many mammalian tissues normally exist at oxygen concentrations well below atmospheric levels.
Researchers increasingly investigate these more physiologically representative conditions, sometimes referred to as physiological oxygen or physoxia.
The adjustable Coy system allows moderate oxygen concentrations to be established as experimental conditions rather than limiting researchers to atmospheric versus near-anoxic environments.
Solid tumors frequently develop regions of reduced oxygen availability.
Hypoxia can influence tumor metabolism, angiogenesis, invasion, gene expression, treatment response, and other aspects of cancer biology.
The Coy cabinet allows tumor-cell cultures to be incubated at defined oxygen concentrations so researchers can investigate these processes under controlled conditions.
Oxygen concentration can influence stem cell proliferation, maintenance, metabolism, differentiation, and phenotype.
A controlled-oxygen cabinet allows researchers to compare stem cell behavior under different oxygen conditions while maintaining appropriate CO₂ and temperature through the surrounding incubator.
This makes the system useful for stem cell and regenerative medicine laboratories seeking tighter environmental control.
Three-dimensional cultures such as spheroids and organoids can develop internal oxygen gradients that differ substantially from conventional monolayer cultures.
Controlling the oxygen concentration surrounding these models can help researchers investigate how environmental oxygen affects growth, metabolism, differentiation, and treatment response.
The Coy cabinet provides a compact platform for these controlled-oxygen incubation studies.
Drug response can depend on cellular oxygen conditions.
A compound tested only under atmospheric oxygen may produce a different response when cells experience hypoxic or physiological oxygen conditions.
Researchers can use the Coy InVitro Cabinet to incorporate oxygen concentration as a controlled variable in drug discovery and translational research.
Coy's current InVitro cabinet platform can also support intermittent hypoxia configurations in which oxygen is cycled between multiple setpoints.
Intermittent hypoxia can be relevant to research involving ischemia/reperfusion, sleep-disordered breathing, cardiovascular physiology, metabolic responses, and other applications.
Dynamic oxygen cycling requires the appropriate control configuration and should not be assumed to be installed on this particular AIE unit unless verified.
A tri-gas incubator combines temperature, CO₂, and oxygen control within a conventional incubator cabinet.
The Coy system takes a modular approach.
A laboratory's existing incubator supplies temperature control, while the hermetically sealed Coy cabinet creates a separate controlled gas environment inside it.
This can provide several advantages for the right laboratory.
Researchers can add hypoxia capability without replacing an existing incubator, and the small sealed volume can reduce the amount of gas required to establish and maintain a selected oxygen concentration.
The choice between the two approaches depends on sample capacity, workflow, available incubator space, and experimental requirements.
The Coy cabinet and a full hypoxia glove-box workstation solve related but different problems.
The Coy InVitro Cabinet is primarily an incubation chamber. Cultures remain under controlled oxygen while inside the sealed cabinet, which itself sits inside an incubator.
A full hypoxia workstation provides a much larger controlled environment with glove ports so researchers can manipulate cultures without exposing them to ambient oxygen.
The Coy cabinet can therefore be an excellent choice when controlled incubation is the priority and manipulation under hypoxia is not required.
A glove-box workstation is more appropriate when feeding, passaging, sampling, or other procedures must also occur continuously under the controlled atmosphere.
Coy itself offers both InVitro cabinets and larger O₂ Control glove boxes.
The cabinet is smaller, simpler, and designed around incubation.
Coy's O₂ Control glove boxes provide glove or sleeve access, an airlock, interior electrical power, and enough workspace to perform experimental manipulations within the controlled atmosphere.
Choosing between them depends largely on whether the experiment only requires controlled incubation or whether researchers must actively work with cultures while maintaining hypoxia.
A hypoxic cabinet should not be confused with an anaerobic chamber.
Hypoxia experiments generally involve deliberately reduced but measurable oxygen concentrations.
Anaerobic systems are designed to eliminate oxygen to extremely low levels for obligate anaerobic organisms or other oxygen-intolerant applications.
The Coy InVitro system's adjustable oxygen control makes it particularly useful when the actual oxygen concentration is an experimental variable.
A conventional CO₂ incubator controls temperature and CO₂ but normally exposes cultures to oxygen concentrations close to atmospheric conditions.
The Coy cabinet adds a separately controlled oxygen environment inside the incubator.
This allows a standard incubator to support hypoxia or physiological oxygen experiments without modifying the incubator's primary atmosphere.
Although this equipment may be grouped with glove boxes for inventory purposes, the Coy InVitro Cabinet is not a glove-access workstation.
Researchers do not continuously manipulate samples through integrated gloves while they remain inside the chamber.
It is more accurately described as a hermetically sealed hypoxic incubation cabinet or controlled-oxygen cell-culture chamber.
This distinction is important for customers comparing hypoxia equipment.
The Coy InVitro Hypoxic Cabinet is not a biological safety cabinet.
Its purpose is atmospheric control rather than HEPA-filtered biological containment.
It should not be relied upon to provide personnel or environmental protection from infectious aerosols or other biological hazards.
Appropriate biosafety containment should be selected separately according to the materials being handled.
The Coy cabinet is also fundamentally different from negative-pressure pharmaceutical containment isolators and HEPA-filtered weighing glove boxes.
Its sealed construction is intended to preserve a controlled gas environment.
It should not automatically be considered suitable for toxic powders, hazardous chemicals, or applications requiring validated personnel containment.
One of the strongest practical advantages of the Coy InVitro system is that it leverages equipment the laboratory may already own.
A research group with an appropriate incubator can add controlled oxygen and CO₂ capability without purchasing another complete temperature-controlled incubator.
This can reduce acquisition cost and conserve valuable laboratory floor space.
The compact cabinet can also dedicate only a portion of an incubator to a specialized oxygen experiment while other equipment remains available elsewhere in the laboratory.
The key question is whether samples need controlled oxygen only during incubation or throughout manipulation.
For experiments in which cells can be removed briefly for processing, a compact hypoxic cabinet may provide the required environmental control at substantially lower cost and complexity.
For experiments where even brief exposure to atmospheric oxygen is undesirable, a full glove-box hypoxia workstation may be the better choice.
The workstation allows feeding, passaging, sampling, and other procedures to occur without leaving the controlled environment.
American Instrument Exchange inspects and tests used hypoxia chambers before shipment.
For this Coy Laboratory InVitro system, AIE technicians inspect the sealed chamber, SP2 oxygen controller, oxygen sensor, AC100 CO₂ controller, circulation fan, pressure relief system, sensor ports, gas connections, shelf, humidification components, seals, and other installed features.
The chamber is visually inspected for cracks, leaks, worn seals, or other physical damage.
AIE also performs a pressure-decay test by pressurizing the chamber and monitoring whether it maintains pressure appropriately.
The environmental control system is operated to verify proper function.
Accessible interior and exterior surfaces are thoroughly cleaned before shipment.
Hypoxia research equipment can represent a significant investment, particularly for laboratories that only need controlled oxygen for a portion of their cell-culture work.
The Coy InVitro Cabinet provides a compact alternative to purchasing a complete hypoxia workstation or dedicated tri-gas incubator.
Its hermetically sealed design, automatic oxygen control, installed CO₂ controller, circulation fan, humidification capability, and compatibility with existing laboratory incubators make it particularly useful for research groups adding controlled-oxygen capability to an established cell-culture laboratory.
American Instrument Exchange inspects, tests, and cleans this used Coy system before shipment and includes a 90-day warranty.
This AIE Coy InVitro Hypoxic Cabinet measures approximately 14 inches wide × 16 inches deep × 15 inches high.
Before purchase, laboratories should confirm that their intended incubator provides adequate internal dimensions and shelf capacity to accommodate the cabinet.
Gas supplies and regulators should be selected according to the intended oxygen and CO₂ control strategy and Coy's operating requirements.
Tubing should be routed so incubator doors and chamber seals close properly without pinching gas lines.
After installation, the oxygen and CO₂ sensors should be appropriately calibrated and chamber performance verified before critical experiments begin.
Laboratories using a Coy InVitro Hypoxic Cabinet may also require CO₂ incubators, tri-gas incubators, hypoxia workstations, biosafety cabinets, inverted microscopes, centrifuges, laboratory refrigerators, laboratory freezers, ultra-low freezers, cryogenic storage systems, water baths, and shakers to support cell culture and biological research.
American Instrument Exchange supplies used and refurbished hypoxia equipment, CO₂ incubators, biosafety cabinets, cold storage, centrifuges, and other laboratory equipment for biotechnology, pharmaceutical, academic, medical, and research laboratories.
The Coy InVitro Hypoxic Cabinet is a hermetically sealed controlled-oxygen chamber designed for cell-culture and hypoxia research. It is intended to operate inside a compatible laboratory incubator.
The surrounding incubator provides temperature control. The Coy system controls the gas environment inside the sealed chamber.
Yes. This AIE system includes a Coy SP2 oxygen controller and sensor.
Coy's InVitro control system allows oxygen setpoints to be adjusted in 0.1% increments.
Yes. It includes a Coy AC100 CO₂ controller.
The CO₂ control system provides a range up to approximately 20%, adjustable in 0.1% increments.
Controlled CO₂ helps maintain appropriate pH in bicarbonate-buffered mammalian cell-culture media.
No. The InVitro cabinet is designed to use the surrounding laboratory incubator for temperature control.
The tight seal helps maintain the selected gas environment and reduces the amount of gas required to maintain controlled oxygen conditions.
Not normally. The controller monitors the oxygen sensor and initiates gas purges when necessary to correct chamber conditions.
Because the sealed chamber retains its atmosphere, gas does not need to flow continuously simply to compensate for leakage.
Yes. The internal fan helps mix the chamber atmosphere and promote consistent gas conditions around samples.
The system includes a humidification tray that can hold water to increase moisture within the chamber.
This particular cabinet measures approximately 14"W × 16"D × 15"H.
Not necessarily. The intended incubator's interior dimensions, shelf arrangement, load capacity, and access should be checked before purchase.
Yes. Controlled hypoxia is widely used in tumor and cancer-cell research where oxygen concentration is an important experimental variable.
Yes. It can support stem-cell experiments investigating how oxygen concentration affects proliferation, differentiation, metabolism, and other cellular responses.
Yes. Adjustable oxygen control allows researchers to establish intermediate oxygen concentrations rather than limiting experiments to atmospheric oxygen or extreme hypoxia.
Potentially. Controlled oxygen can be an important experimental variable in three-dimensional culture models such as organoids and spheroids.
A tri-gas incubator controls temperature, CO₂, and oxygen throughout its entire cabinet. The Coy system creates a smaller sealed controlled-gas environment inside an existing incubator.
A full workstation allows researchers to manipulate cells through glove ports while maintaining controlled oxygen. The Coy InVitro Cabinet is primarily designed to maintain controlled conditions during incubation.
It is not designed as a glove-access workspace. If passaging must occur without exposure to ambient oxygen, a full hypoxia glove box or workstation is more appropriate.
No. It is designed for controlled oxygen experiments across hypoxic and other defined oxygen conditions rather than specifically maintaining the near-zero oxygen environment required for anaerobic culture.
No. The Coy InVitro Cabinet controls the gas environment and should not be substituted for a biosafety cabinet when biological containment is required.
HEPA containment is not a standard defining feature of the Coy InVitro Hypoxic Cabinet. It should not be assumed to provide personnel protection from hazardous aerosols or particulates.
Coy offers dynamic oxygen-cycling capability for its InVitro cabinet platform. That functionality depends on the installed controller and configuration and should be verified before assuming this particular unit supports automated cycling protocols.
Gas requirements depend on the desired oxygen and CO₂ conditions. Nitrogen is commonly used to reduce oxygen, while CO₂ and oxygen may be supplied when independent upward control of those gases is required.
Yes. American Instrument Exchange includes a 90-day warranty with this used and refurbished Coy InVitro Hypoxic Cabinet System.
AIE technicians inspect the chamber, seals, gas connections, circulation fan, O₂ and CO₂ controllers, sensors, and other installed components. A pressure-decay test is also performed to evaluate chamber integrity before shipment.
Click Here to see the Coy Lab Product Hypoxic cabinet system on the American Instrument Exchange YouTube channel.
Yes, all equipment from American Instrument Exchange comes with a warranty.
Used/reconditioned/refurbished equipment is tested to make sure it operates to the manufacturer's specifications and comes with a 90-day warranty (unless otherwise noted). New equipment comes with a warranty from the manufacturer.
Testing requirements vary across all the equipment categories we sell. Temperature controlled units are tested with NIST traceable probes and data loggers. Gaskets, external housing, glass, handles, controls and control screens are all thoroughly inspected for integrity and functionality.
We test all equipment using the manufacturer's parameters and specifications to confirm that the unit operates properly.
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