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Thermo Scientific CryoPlus™ 4 Liquid Nitrogen Storage System
As biological collections grow, the challenge shifts from simply preserving samples to managing thousands—or even tens of thousands—of specimens safely and efficiently. The Thermo Scientific CryoPlus™ 4 Liquid Nitrogen Storage System was developed for laboratories that require large-scale cryogenic storage with dependable automation, intelligent monitoring, and long-term sample protection. Designed for biobanks, cell therapy programs, pharmaceutical manufacturers, and research institutions, the CryoPlus 4 combines high-capacity liquid nitrogen storage with microprocessor-controlled operation to safeguard valuable biological collections.
With approximately 550 liters of liquid nitrogen capacity and storage for up to 38,500 standard 2.0 mL cryovials, the CryoPlus 4 provides one of the largest storage capacities within the CryoPlus family while maintaining automated liquid nitrogen level control, integrated alarms, and flexible rack configurations. Rather than serving as a freezing device, the CryoPlus 4 is designed for long-term preservation after samples have completed the controlled-rate freezing process.
A complete cryopreservation workflow often begins with sample preparation inside biosafety cabinets, continues through controlled freezing using a Thermo Scientific CryoMed Controlled-Rate Freezer, and concludes with long-term preservation inside a cryogenic storage system such as the CryoPlus 4. Many laboratories also maintain ultralow freezers for intermediate storage or applications that do not require liquid nitrogen temperatures.
Thermo Scientific CryoPlus™ 4 Key Features
Approximately 550 L liquid nitrogen capacity
Stores up to 38,500 standard 2.0 mL cryovials
Automatic liquid nitrogen refill system
Vapor-phase or liquid-phase storage capability
Microprocessor controller
Automatic liquid level monitoring
Audible and visual alarm system
Remote alarm capability
Vacuum-insulated stainless steel vessel
Flexible rack and inventory configurations
Refurbished and performance tested by American Instrument Exchange
90-day warranty included
Thermo Scientific CryoPlus™ 4 Overview
The CryoPlus 4 was engineered for organizations that manage large biological repositories where inventory control, automation, and long-term reliability are just as important as storage temperature. By combining a vacuum-insulated stainless steel vessel with automated liquid nitrogen management, the system minimizes manual intervention while helping maintain consistent cryogenic storage conditions.
The integrated microprocessor controller continuously monitors liquid nitrogen levels and operating status while managing automatic refill cycles. Audible and visual alarms, remote monitoring capability, and configurable rack systems allow laboratories to organize extensive collections while reducing the risks associated with manual liquid nitrogen management.
Common Applications
The Thermo Scientific CryoPlus 4 is commonly used for:
Cell banking
Stem cell preservation
Cell therapy manufacturing
CAR-T therapy storage
PBMC repositories
Cord blood banking
Embryo and oocyte storage
Sperm banking
Tissue repositories
Biopharmaceutical sample archives
Clinical trial specimen storage
Long-term biobanking
Its large storage capacity makes it particularly well suited for centralized biorepositories and organizations managing high-volume cryogenic inventories.
Ideal Laboratory Types
The CryoPlus 4 is an excellent choice for:
Cell therapy manufacturing facilities
Biotechnology companies
Pharmaceutical manufacturers
Academic medical centers
Biobanks
IVF laboratories
Clinical research organizations
Government research facilities
GMP manufacturing environments
Why Large-Capacity Cryogenic Storage?
For many laboratories, inventory growth eventually outpaces smaller liquid nitrogen systems. Consolidating thousands of samples into a high-capacity storage vessel can simplify inventory management, reduce floor space requirements, and standardize cryogenic workflows across multiple research groups.
The CryoPlus 4 supports both vapor-phase and liquid-phase storage depending on laboratory protocols while automatically maintaining liquid nitrogen levels. When combined with a controlled-rate freezing system, it becomes the final stage in a comprehensive cryopreservation program designed to maximize long-term sample viability.
Typical Stored Materials
The CryoPlus 4 is commonly used to preserve:
Stem cells
Cell lines
PBMCs
CAR-T products
Cord blood
Bone marrow
Embryos
Oocytes
Sperm
DNA repositories
Tissue specimens
Long-term research collections
Thermo Scientific CryoPlus™ 4 Key Specifications
Liquid Nitrogen Capacity
Approximately 550 liters
Storage Capacity
Up to 38,500 standard 2.0 mL cryovials
Storage Temperature
Approximately -135°C to -196°C, depending on storage configuration
Monitoring & Controls
Microprocessor controller
Automatic liquid nitrogen refill
Liquid level monitoring
Audible and visual alarms
Remote alarm capability
RS-232 / RS-485 communications
Construction
Vacuum-insulated stainless steel vessel
Electrical Requirements
Available in 100–120V or 200–230V configurations
Operating Costs & Liquid Nitrogen Management
Unlike mechanical freezers, the CryoPlus 4 relies on liquid nitrogen rather than compressors to maintain cryogenic temperatures. Operating costs are primarily influenced by liquid nitrogen usage, refill frequency, storage configuration, and laboratory workflow. Automated level management reduces operator involvement while helping maintain stable storage conditions for valuable biological collections.
Specifications compiled from Thermo Scientific manufacturer literature and American Instrument Exchange product information.
Refurbishment & Testing Process
Every Thermo Scientific CryoPlus 4 received by American Instrument Exchange undergoes a comprehensive inspection and operational evaluation before shipment. Our technicians verify controller operation, alarm functionality, automatic fill controls, liquid level sensing, vacuum vessel integrity, communication interfaces, and overall system performance before thoroughly cleaning the unit for delivery.
The CryoPlus 4 ships by freight from American Instrument Exchange. Before installation, laboratories should verify floor loading capacity, electrical service, adequate ventilation, and access to a reliable liquid nitrogen supply. Because liquid nitrogen can displace oxygen in enclosed spaces, installations should comply with institutional safety procedures regarding ventilation, oxygen monitoring, and personal protective equipment.
How does the CryoPlus 4 differ from the CryoPlus 1?
The CryoPlus 4 is designed for much larger cryogenic repositories, offering significantly greater liquid nitrogen capacity and storage for up to approximately 38,500 2.0 mL cryovials, making it well suited for centralized biobanking and high-volume research collections.
Is the CryoPlus 4 used for freezing samples?
No. The CryoPlus 4 is designed for long-term cryogenic storage. Samples are typically frozen first using a controlled-rate freezer before being transferred into the CryoPlus system.
Can the CryoPlus 4 support vapor-phase storage?
Yes. The CryoPlus platform supports both liquid-phase and vapor-phase storage, allowing laboratories to select the configuration that best matches their protocols and regulatory requirements.
How is the CryoPlus 4 tested before shipment?
Every refurbished Thermo Scientific CryoPlus 4 is inspected and operationally tested by American Instrument Exchange technicians to verify controller functionality, automatic fill operation, liquid level monitoring, alarm systems, and overall operational performance before shipment.
Testing Procedures for Used and Refurbished Laboratory Freezers
Cold Storage Reliability from American Instrument Exchange
At American Instrument Exchange, every used and refurbished laboratory freezer we offer undergoes a comprehensive multi-point testing protocol to ensure optimal performance, temperature stability, and long-term reliability. Our rigorous testing procedures are designed to meet the demanding standards of biomedical, pharmaceutical, research, and clinical environments—so you can trust your freezer to protect your valuable samples and materials.
Why Testing Refurbished Laboratory Freezers Is Critical
Before any laboratory freezer is placed back into service, it must be carefully tested for:
Consistent temperature control and uniformity across internal zones
Compressor functionality and refrigeration system performance
Seal integrity and insulation efficiency to prevent temperature loss
Electrical safety and alarm system operation
Thorough testing minimizes the risk of temperature excursions, equipment failure, and product loss—especially for temperature-sensitive items like reagents, biological samples, and vaccines.
Our structured testing protocol ensures that all used and refurbished laboratory freezers meet or exceed manufacturer specifications and industry expectations.
Key Testing Procedures for Laboratory Freezers
1. Visual and Structural Inspection
Examine the exterior for dents, corrosion, or physical damage
Check door gaskets, hinges, and latches for wear and functionality
Inspect power cords, control panels, and internal compartments
2. Functional Startup and System Check
Power on the unit to verify startup sequence, control panel functionality, and display readability
Test programmable settings, alarms, and door-open sensors
Ensure proper door closure and sealing performance
3. Temperature Performance and Stability Testing
Test temperature sensors using certified thermometers or probes
Monitor chamber temperature at multiple points over extended run periods
Verify temperature uniformity and accuracy across common lab setpoints (e.g., -20°C, -30°C)
4. Compressor and Refrigeration System Evaluation
Test compressor startup, cycling behavior, and operating noise
Check condenser coils, evaporators, and fans for performance and cleanliness
Inspect for refrigerant leaks or pressure issues that may affect efficiency
5. Electrical Safety and Compliance Verification
Confirm proper grounding and insulation of all electrical components
Conduct safety testing to meet laboratory equipment electrical standards
Verify functionality of alarms for power loss, temperature excursions, and system faults
6. Final Quality Assurance and Runtime Validation
Conduct multi-day test cycle to confirm stable performance under continuous use
Record temperature data, alarm responses, and compressor cycling metrics
Complete final inspection and prepare detailed service documentation
Reliable Cold Storage, Backed by Testing Excellence
Each refurbished laboratory freezer from American Instrument Exchange is tested and certified for cold storage accuracy, safety, and performance. Whether upright, undercounter, flammable-material rated, or specialty-purpose, our lab freezers are restored to meet real-world research and clinical demands.
Trust American Instrument Exchange for dependable, tested, and warrantied laboratory refrigeration—ready to support your lab from day one.
Repair and Refurbishment Protocol for Used Laboratory Freezers Certified Cold Storage Performance from American Instrument Exchange
At American Instrument Exchange, every used laboratory freezer we offer is subjected to a comprehensive repair and refurbishment protocol. Whether it’s a general-purpose lab freezer, flammable-material grade unit, or undercounter model, our goal is to restore each system to peak performance—ensuring consistent temperature control and reliable operation.
Why Choose a Refurbished Laboratory Freezer from American Instrument Exchange?
• Fully tested for cold storage accuracy and operational safety
• Backed by a warranty
• Cost-effective alternative to new refrigeration equipment
• Sustainably refurbished to reduce environmental impact
• Serviced by expert technicians with decades of laboratory equipment experience
Step-by-Step Refurbishment Protocol
Every laboratory freezer from American Instrument Exchange follows a detailed, multi-stage process to ensure top-tier performance and reliability:
1. Initial Intake & Inspection
• Visual inspection for dents, corrosion, or structural damage
• Mechanical check of door hinges, gaskets, seals, and internal components
• Documentation of missing parts or areas requiring repair or replacement
2. Cleaning and Decontamination
• Internal and external cleaning using non-abrasive cleaners
• Decontamination/cleaning of all surfaces to remove biological or chemical residues
• Thorough cleaning of shelving, drawers, and removable interior parts
3. Mechanical and Electrical Repairs
• Replacement or repair of worn mechanical parts (door latches, seals, hinges, etc.)
• Inspection and restoration of control interfaces, thermostats, sensors, and displays
• Evaluation of wiring, relays, fuses, and power supply components for safety and integrity
4. Refrigeration System and Compressor Evaluation
• Testing of compressor function, condenser coils, and evaporators
• Inspection for refrigerant leaks and pressure performance (if applicable)
• Verification of proper airflow, fan operation, and defrost cycles
5. Temperature Calibration and Performance Testing
• Testing of temperature sensors and control boards
• Verification of temperature stability and uniformity throughout the chamber
• Testing of multiple setpoints (e.g., -20°C to -30°C) over extended operating periods
6. Safety and Compliance Checks
• Inspection of grounding and electrical insulation per lab safety standards
• Testing of alarm systems (if applicable) for temperature excursions or power failure
7. Final Quality Control and Documentation
• Multi-day operational test
• Final cleaning, inspection, and performance validation
• Detailed service report with temperature logs and repair notes
Trust the Experts at American Instrument Exchange
With over 50 years of industry experience, American Instrument Exchange is a leading provider of high-quality refurbished laboratory equipment. Our proven laboratory refrigerator refurbishment protocol ensures consistent, accurate cold storage—so you can safeguard your samples with confidence.
Warranty Information
All used equipment sold by American Instrument Exchange is refurbished/reconditioned, tested to meet specifications, cleaned, and comes with a 90-day warranty from the date of shipment unless otherwise specified. New products include a warranty from the manufacturer. Your warranty is only valid if you have paid your invoice. If your invoice is over 30 days old, warranty work will not be performed until your invoice is paid in full. American Instrument Exchange is not liable for any special or consequential damages that result from the use of, or the inability to use, the materials on this site or the performance of the products,
Exceptions include international sales and items that are agreed to be sold with a lesser warranty or items that are agreed to be sold “as is.”
Should there be visible shipping damage to packaging or concealed shipping damage to item(s) supplied, buyer must communicate such damage to the delivering entity or carrier upon receipt first and to American Instrument the same day item is accepted / signed for. Failure to do so voids warranty. Customer decision to involve / procure third party or OEM service other than American Instrument or AIE assigned vendors to resolve in-warranty instrument failure or defect without first placing a service call to American Instrument voids warranty.
Return & Cancellation Policy
American Instrument Exchange will authorize the return of and issue a full refund for any equipment that is not working as represented and could not be replaced or repaired to the customer’s satisfaction by AIE or a representative of AIE during the warranty period. Returns without prior authorization and an RMA number will not be accepted.
Customers are responsible for proper packaging of the equipment and all included accessories. American Instrument will pay for insurance and shipping costs. Non-inventory items bought specifically to fill customer orders may possibly be returned, but on a case by case basis.
Customers who cancel orders after refurbishing has begun or after delivery where there are no equipment performance issues may be subject to a Restocking/Cancellation Fee of 20% or more and responsible for shipping costs for both the delivery and return.
Ongoing and Extended Support Options
American Instrument Exchange is able to provide additional repair and support services outside the warranty terms for most products that sell.
For biosafety cabinets, clean benches, chemical fume hoods, and other clean air products our team at AIE Laboratory Services can provide certifications, repairs, decontaminations, and other services for customers throughout New England, and guidance and limited technical assistance for any customers in the US and Canada for new or refurbished biosafety cabinets purchased from American Instrument Exchange.
For all other products, the repair service team at American Instrument Exchange can provide both field and depot repair evaluations. We can easily schedule and coordinate the pick-up and transportation of your malfunctioning equipment. By offering hourly rates lower than most OEM service providers and eliminating travel time for technicians, we help reduce repair costs. Furthermore, our lab depot repair service minimizes or eliminates scheduling delays. Our experienced service technicians are qualified to restore your equipment to factory specifications.
Yes, all equipment from American Instrument Exchange comes with a warranty. Used/reconditioned/refurbished equipment is tested to make sure it operates to the manufacturer's specifications and comes with a 90-day warranty (unless otherwise noted). New equipment comes with a warranty from the manufacturer.
How do you test and recondition the equipment?
Testing requirements vary across all the equipment categories we sell. Temperature controlled units are tested with NIST traceable probes and data loggers. Gaskets, external housing, glass, handles, controls and control screens are all thoroughly inspected for integrity and functionality. We test all equipment using the manufacturer's parameters and specifications to confirm that the unit operates properly.
How do products ship from American Instrument Exchange?
We can ship products both nationally and internationally using a well-established network of transporters. Smaller items will ship via UPS. Larger equipment will be palletized and shipped either LTL or air-ride, depending on the specific equipment and/or delivery requirements.
Return and order cancellation policy
American Instrument Exchange will accept the return of any product that is not working as represented and could not be replaced or repaired to the customer's satisfaction during the warranty period. Customers who cancel orders after refurbishing has begun will be subject to a cancellation and restocking fee of between 20% and 40%.
Are discounts available for educational or non-profit institutions, or for bulk purchases?
Yes – call or email us today with a list of equipment you're looking for and we can potentially put together a quote that includes a discount.
How does your price matching policy work?
We strive to keep our pricing competitive and reasonable. If you find comparable items for sale at a lower price from other vendors please send us a link and or quote for the item and we'll do our best to match or beat the price.
Can I see the equipment in person before committing to a purchase?
Customers are welcome to make an appointment to view equipment in our warehouse. Given our workload we may not be able to test or clean the equipment prior to your arrival if you have not committed to an order.
1023 Western Avenue is a working warehouse, not a showroom, and customers should dress appropriately and wear closed toe shoes.
Can I ship products that I purchased elsewhere to American Instrument for repair?
Yes – please see our repair services page for more information.
