Sartorius Secura SECURA125-1S Semi-Micro Balance – New
The Sartorius Secura SECURA125-1S Semi-Micro Balance provides 120 g maximum capacity with 0.01 mg / 10 µg readability across its full weighing range, giving laboratories semi-micro sensitivity without the range switching required by a dual-range balance.
Available brand new from American Instrument Exchange, the SECURA125-1S combines high-resolution weighing with Sartorius isoCAL automatic internal adjustment, Real-Time Level Support, SQmin minimum-weight monitoring, USP compliance support, a color touchscreen, calibration history, password protection, and a manual draft shield designed for sensitive analytical work.
Unlike the dual-range SECURA225D-1S, the SECURA125-1S maintains its 0.01 mg readability throughout the entire 120 g capacity. This makes it particularly attractive for laboratories that consistently require 10 µg resolution and do not need the additional 220 g full-range capacity of the dual-range model.
This balance is supplied new and includes the applicable Sartorius manufacturer warranty.
Key Features
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120 g maximum weighing capacity
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0.01 mg / 10 µg readability across the full range
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Typical repeatability as low as 0.02 mg
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0.1 mg linearity limit
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Typical stabilization time of ≤4 seconds
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Optimum USP minimum initial weight of approximately 8.2 mg
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isoCAL automatic internal adjustment
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Real-Time Level Support
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SQmin minimum-weight monitoring
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USP and PhEur weighing support
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Color touchscreen display
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Manual draft shield
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218 mm weighing-chamber height
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80 mm diameter weighing pan
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Calibration history
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Configurable safety levels
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Password protection
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Sample identification
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GLP/GMP documentation support
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Mini USB interface
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PC-direct data transfer
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Plug & Play connectivity to compatible Sartorius printers
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Brand new from American Instrument Exchange
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Sartorius manufacturer warranty included
Overview
The Sartorius SECURA125-1S is a single-range semi-micro balance designed for laboratories that need greater sensitivity than a conventional analytical balance.
A typical analytical balance provides 0.1 mg readability.
The SECURA125-1S provides 0.01 mg readability, giving users ten times finer displayed resolution.
Because that 10 µg readability remains available throughout the entire 120 g weighing range, the Secura 125 is particularly straightforward to use for methods requiring consistent semi-micro resolution.
The balance is designed not only to produce highly sensitive weight measurements but also to help users recognize conditions that could compromise those results.
Features such as Real-Time Level Support, isoCAL automatic adjustment, SQmin, calibration history, and controlled data-transfer functions help integrate weighing into a more structured laboratory workflow.
Common Applications
The SECURA125-1S is well suited for pharmaceutical formulation, standards preparation, analytical chemistry, gravimetric analysis, biotechnology research, quantitative sample preparation, quality control, reference-material weighing, density determination, mixture preparation, and other procedures requiring 10 µg resolution.
Pharmaceutical laboratories can use the balance for active ingredients, reference standards, formulation components, stability testing, and quantitative analytical procedures.
Biotechnology laboratories may use it for small quantities of compounds, reagents, membranes, filters, powders, and research materials.
Chemical and analytical laboratories can use the Secura for standards preparation, gravimetric procedures, and other workflows where 0.1 mg analytical readability does not provide sufficient resolution.
Ideal Laboratory Types
The SECURA125-1S is especially well suited for pharmaceutical manufacturers, biotechnology companies, analytical laboratories, contract testing organizations, chemical laboratories, research universities, quality-control departments, and regulated facilities.
It is particularly useful in laboratories where semi-micro measurements are performed routinely rather than occasionally.
Because the balance provides 10 µg readability over its entire 120 g capacity, technicians do not need to manage a separate fine-range transition during normal operation.
Single-Range Semi-Micro Weighing Performance
The defining characteristic of the SECURA125-1S is its single-range architecture.
The balance provides 120 g maximum capacity with 0.01 mg readability throughout the range.
Sartorius specifies typical repeatability of approximately 0.02 mg at lower loads and approximately 0.03 mg near maximum capacity.
The linearity limit is ±0.1 mg.
Typical stabilization time is ≤4 seconds.
This combination allows the SECURA125-1S to support demanding semi-micro procedures while still providing enough capacity for common weighing vessels, sample containers, and tare materials.
Understanding 10 µg Readability
A readability of 0.01 mg is equivalent to 10 micrograms.
This is ten times finer than the 0.1 mg readability associated with a conventional analytical balance.
That additional resolution can be valuable when working with very small samples or when the quantitative uncertainty of an analytical balance becomes too large relative to the sample mass.
However, readability should not be confused with minimum sample weight.
A balance may display changes of 0.01 mg without every possible sample mass meeting the uncertainty requirements of a regulated weighing method.
Minimum Sample Weight & USP Applications
Sartorius specifies an optimum minimum initial weight according to USP Chapter 41 of approximately 8.2 mg for the SECURA125-1S.
The manufacturer also identifies a typical minimum initial weight of approximately 40 mg under normal conditions.
The difference reflects the fact that minimum sample weight depends on repeatability, environmental conditions, installation quality, and the uncertainty criteria applied by the laboratory.
For regulated work, laboratories should therefore establish the actual minimum weight under their own operating conditions rather than treating readability as the minimum permissible sample size.
The Secura platform includes SQmin and USP-oriented monitoring features to help laboratories manage this requirement.
SQmin Minimum-Weight Monitoring
SQmin allows the balance to compare the current sample mass against a defined minimum-weight threshold.
This can help prevent technicians from unknowingly weighing samples below the laboratory's validated operating range.
For pharmaceutical and regulated laboratories, this is an important distinction.
A numerical result may appear stable on the display while still falling below the minimum sample mass required to satisfy the applicable measurement uncertainty.
SQmin gives the operator an additional safeguard during routine weighing.
USP & PhEur Support
The Secura platform was developed with regulated weighing applications in mind.
Minimum-weight support and operator guidance can help laboratories follow USP and European Pharmacopoeia weighing requirements.
The balance does not eliminate the need for laboratory-specific qualification, verification, or SOP development.
Instead, it provides tools that make those procedures easier to implement consistently.
isoCAL Automatic Internal Adjustment
The SECURA125-1S incorporates Sartorius isoCAL automatic internal adjustment.
The system uses an internal reference weight and automatically initiates adjustment when defined temperature or time conditions are reached.
Current Sartorius specifications identify a 1.5 K temperature-change trigger and a four-hour time interval for isoCAL operation.
This is particularly valuable for semi-micro weighing because small environmental changes can have a greater influence on highly sensitive measurements.
Automatic adjustment reduces reliance on technicians remembering to perform routine manual calibration procedures.
External verification with certified weights may still be required under the laboratory's quality program.
Real-Time Level Support
Correct leveling is important for accurate balance performance.
The SECURA125-1S incorporates Real-Time Level Support to continuously monitor whether the instrument is properly leveled.
If the balance is moved, cleaned, repositioned, or installed on an unsuitable surface, the system can alert the operator that leveling requires attention.
This helps reduce the risk of questionable measurements caused by an improperly installed balance.
Controlling Drafts, Vibration & Static
At 0.01 mg readability, environmental conditions can have a significant effect on weighing performance.
Air movement from HVAC outlets, doors, fans, or nearby activity may cause instability.
Mechanical vibration from centrifuges, shakers, pumps, compressors, or foot traffic can also make sensitive measurements more difficult.
Static charge can affect lightweight samples, plastic vessels, powders, filters, and other insulating materials.
The SECURA125-1S uses a manual draft shield with coated glass components designed to help reduce electrostatic influences.
For demanding work, laboratories should also use a stable balance table and appropriate anti-static practices.
Sample Temperature & Air Buoyancy
Samples should ideally be close to room temperature before high-resolution weighing begins.
Warm or cold samples can create convection currents inside the draft shield, causing apparent changes in mass.
Temperature differences can also affect density and air-buoyancy behavior.
Allowing samples, containers, and calibration weights to equilibrate with the balance environment can therefore improve repeatability.
These effects become increasingly important as readability moves from conventional analytical levels into the semi-micro range.
Manual Draft Shield
The SECURA125-1S uses a manual draft shield to protect the weighing pan from air currents.
Sartorius specifies a weighing-chamber height of approximately 218 mm.
This provides sufficient vertical clearance for many common weighing vessels while maintaining a controlled environment around the 80 mm diameter pan.
The draft-shield glass is coated to help reduce electrostatic influences.
Color Touchscreen Interface
The Secura uses a color touchscreen interface to provide access to weighing functions, applications, calibration information, system settings, and operator guidance.
This simplifies navigation compared with older balances that rely on abbreviated menu codes or combinations of physical keys.
A graphical interface can also reduce training requirements in laboratories where multiple technicians share the instrument.
Built-In Weighing Applications
The Secura platform supports a broad range of weighing applications.
These include standard weighing, density determination, percentage weighing, checkweighing, peak hold, counting, unstable-condition monitoring, animal weighing, mixture preparation, component weighing, statistics, and unit conversion.
Built-in applications can reduce manual calculations and help standardize repetitive laboratory procedures.
Data Integrity & Result Transfer
One of the Secura platform's more useful workflow features is its ability to monitor weighing conditions before results are transferred.
If the balance identifies questionable operating conditions, it can prevent uncertain results from being sent to a connected printer or computer.
This provides an additional level of quality control beyond simply displaying a number.
For regulated laboratories, preventing questionable results from entering downstream records can be as important as identifying the problem on the balance itself.
Calibration History
The Secura maintains calibration and adjustment information that can be reviewed by the user.
Calibration history can support instrument oversight and troubleshooting.
For quality-controlled laboratories, the ability to review adjustment activity can also contribute to traceability and documentation.
Password Protection & Safety Levels
The SECURA125-1S includes password protection and configurable safety settings.
Three safety levels allow laboratories to determine how much control individual users have over instrument settings and procedures.
This can help prevent accidental or unauthorized configuration changes.
In regulated environments, limiting access to critical settings can make routine procedures easier to standardize.
GLP/GMP Documentation
The Secura supports GLP/GMP-oriented documentation when used with compatible output devices.
Measurement and calibration information can be transferred electronically or sent to a compatible Sartorius printer.
Sample identification capability further supports traceability.
These features can help laboratories integrate weighing into established documentation systems.
Connectivity
The SECURA125-1S provides a Mini USB interface and supports direct transfer of data to compatible Windows applications.
Available data-transfer protocols include Sartorius SBI, table-format output, and text-format output.
Programmable output intervals are also supported.
Plug & Play connectivity is available for compatible Sartorius printers.
Key Specifications
| Specification |
Sartorius SECURA125-1S |
| Balance Type |
Semi-Micro Balance |
| Weighing Architecture |
Single Range |
| Maximum Capacity |
120 g |
| Readability |
0.01 mg / 10 µg |
| Typical Repeatability, Lower Load |
±0.02 mg |
| Typical Repeatability, Near Maximum Load |
±0.03 mg |
| Linearity Limit |
±0.1 mg |
| Typical Linearity |
±0.06 mg |
| Typical Stabilization Time |
≤4 seconds |
| Typical Measurement Time |
≤6 seconds |
| Optimum Minimum Initial Weight, USP Ch. 41 |
Approx. 8.2 mg |
| Typical Minimum Initial Weight |
Approx. 40 mg |
| Adjustment |
Internal Automatic / isoCAL |
| isoCAL Temperature Trigger |
1.5 K |
| isoCAL Time Interval |
4 hours |
| Recommended External Test Weight |
100 g, E2 |
| Leveling |
Real-Time Level Support |
| SQmin Function |
Yes |
| Draft Shield |
Manual |
| Weighing Chamber Height |
218 mm |
| Weighing Pan |
Ø80 mm |
| Display |
Color Touchscreen |
| Housing Protection |
IP43 |
| Calibration History |
Yes |
| Password Protection |
Yes |
| Safety Levels |
Three Configurable Levels |
| Sample Identification |
Yes |
| Data Interface |
Mini USB |
| PC-Direct Data Transfer |
Yes |
| GLP/GMP Support |
Yes |
| Dimensions |
218 mm W × 376 mm D × 316 mm H |
| Net Weight |
Approx. 8.8 kg |
| Electrical |
100–240 V, 50–60 Hz |
| Condition |
New |
| Warranty |
Sartorius Manufacturer Warranty |
SECURA125-1S vs. SECURA225D-1S
The SECURA125-1S and SECURA225D-1S share many of the same Secura quality and workflow features, but their weighing architectures are different.
The SECURA125-1S is a single-range model providing 120 g capacity with 0.01 mg readability throughout the range.
The SECURA225D-1S is a dual-range model providing 0.01 mg readability within its fine range and 0.1 mg readability up to a full 220 g capacity.
The 125 is therefore ideal when consistent semi-micro resolution is the priority.
The 225D is more appropriate when technicians need both semi-micro performance and additional capacity for heavier loads.
Single-Range vs. Dual-Range Semi-Micro Balances
A single-range balance provides the same readability throughout its entire capacity.
This simplifies method development because users do not need to account for transitions between fine and coarse ranges.
A dual-range balance provides additional total capacity while restricting its finest readability to part of the weighing range.
Neither architecture is inherently better.
The appropriate choice depends on the mass of typical containers, tare requirements, and whether users routinely need capacity above 120 g.
SECURA125-1S vs. Conventional 0.1 mg Analytical Balance
A conventional analytical balance provides 0.1 mg readability.
The SECURA125-1S provides 0.01 mg readability.
This tenfold increase in displayed resolution can significantly reduce relative uncertainty when working with small samples.
For routine analytical work involving samples comfortably above the minimum-weight requirements of a 0.1 mg balance, the additional sensitivity may not be necessary.
For small standards, low-mass formulations, filters, or procedures requiring tighter quantitative control, semi-micro performance can provide a meaningful advantage.
SECURA125-1S vs. Secura Micro Balance
The Secura microbalance extends sensitivity beyond the semi-micro range.
The SECURA125-1S provides 120 g capacity with 0.01 mg readability.
The Secura microbalance provides substantially finer resolution but much lower total capacity.
Semi-micro balances therefore provide a useful compromise for laboratories that need greater sensitivity than an analytical balance but still need enough capacity for routine sample vessels.
Choosing a Semi-Micro Balance for Regulated Work
In regulated environments, weighing performance is only part of the instrument-selection decision.
Laboratories must also consider minimum-weight monitoring, adjustment, leveling, access control, documentation, data transfer, and the ability to prevent questionable results from entering laboratory records.
The SECURA125-1S addresses these concerns with SQmin, Real-Time Level Support, isoCAL, password protection, configurable safety levels, calibration history, sample identification, and controlled data transfer.
This makes the balance especially suitable for pharmaceutical and quality-control environments where weighing procedures must be both sensitive and well controlled.
New Sartorius Secura Balances from American Instrument Exchange
This Sartorius SECURA125-1S Semi-Micro Balance is offered brand new through American Instrument Exchange.
It is not used or refurbished equipment.
The balance is supplied as new equipment and includes the applicable Sartorius manufacturer warranty.
For laboratories requiring 10 µg readability throughout a full 120 g range, automatic internal adjustment, minimum-weight support, touchscreen operation, and integrated compliance safeguards, the SECURA125-1S provides a sophisticated solution for demanding analytical weighing.
Shipping & Installation Considerations
The SECURA125-1S should be installed on a rigid, level, vibration-resistant balance table.
Direct airflow from HVAC vents, fans, doors, or nearby movement should be minimized.
Vibrating equipment such as centrifuges, shakers, pumps, and compressors should not share the same bench when highly sensitive measurements are being performed.
After installation, the balance should be leveled and allowed to equilibrate to room conditions.
Samples, containers, and calibration weights should also be allowed to reach similar temperatures whenever possible.
Static control may be necessary when working with powders, filters, plastics, or other insulating materials.
Laboratories performing regulated procedures should verify minimum sample weight and weighing performance under their actual installation conditions before placing the instrument into routine use.
Related Laboratory Equipment
American Instrument Exchange maintains an extensive inventory of used, refurbished, and new laboratory balances, including analytical balances, semi-micro balances, microbalances, and precision balances for applications ranging from routine sample preparation to high-resolution quantitative analysis.
Labs developing complete analytical or sample-preparation workflows can also source centrifuges, water baths, incubators, laboratory refrigerators, laboratory freezers, and other laboratory equipment from American Instrument Exchange.
Sartorius Secura SECURA125-1S Semi-Micro Balance FAQs
What is the maximum capacity of the SECURA125-1S?
The SECURA125-1S has a maximum weighing capacity of 120 g.
What is the readability?
The balance provides 0.01 mg, or 10 µg, readability throughout the full 120 g weighing range.
Is the SECURA125-1S a semi-micro balance?
Yes. Sartorius classifies the SECURA125-1S as a semi-micro balance.
Is the SECURA125-1S single range or dual range?
It is a single-range balance. Its 0.01 mg readability remains available throughout the entire 120 g capacity.
What is the repeatability?
Sartorius lists typical repeatability of approximately 0.02 mg at lower loads and approximately 0.03 mg near maximum capacity.
What is the linearity?
The manufacturer specifies a linearity limit of ±0.1 mg, with typical linearity around ±0.06 mg.
What is the optimum USP minimum sample weight?
Sartorius's current model-specific data lists an optimum USP Chapter 41 minimum initial weight of approximately 8.2 mg.
What is the typical minimum sample weight?
Sartorius lists a typical minimum initial weight of approximately 40 mg, although actual minimum weight depends on installation and environmental conditions.
Does the SECURA125-1S have internal calibration?
Yes. The balance includes Sartorius isoCAL automatic internal adjustment.
What triggers isoCAL?
Current Sartorius specifications identify an approximately 1.5 K temperature change and a four-hour time interval as isoCAL adjustment criteria.
What is Real-Time Level Support?
Real-Time Level Support monitors balance leveling and helps alert operators when adjustment is required.
What is SQmin?
SQmin is a minimum-weight monitoring function that helps users determine whether a sample meets a defined minimum weighing requirement.
Does the SECURA125-1S have a draft shield?
Yes. It includes a manual draft shield with approximately 218 mm of chamber height.
What size is the weighing pan?
The weighing pan is approximately 80 mm in diameter.
Does the balance have a touchscreen?
Yes. The Secura uses a color touchscreen interface.
Can results be transferred directly to a computer?
Yes. The balance includes Mini USB connectivity and supports direct transfer to compatible Windows applications.
What is the difference between SECURA125-1S and SECURA225D-1S?
The SECURA125-1S provides 120 g capacity with 0.01 mg readability throughout its full range. The SECURA225D-1S adds a higher-capacity range up to 220 g but uses 0.1 mg readability in that portion of the range.
Is this Sartorius Secura new or refurbished?
This SECURA125-1S is offered brand new through American Instrument Exchange and includes the applicable Sartorius manufacturer warranty.
Why choose the Sartorius SECURA125-1S?
The SECURA125-1S combines 120 g capacity, full-range 10 µg readability, isoCAL automatic adjustment, Real-Time Level Support, SQmin, USP minimum-weight support, a color touchscreen, controlled data transfer, calibration history, and security features in a semi-micro balance designed for demanding analytical and regulated laboratory workflows.
