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Thermo Forma CryoPlus 4 Liquid Nitrogen Storage System
For laboratories preserving irreplaceable biological materials, maintaining temperatures below the capabilities of even the best ultra-low freezer is often essential. The Thermo Forma CryoPlus 4 Liquid Nitrogen Storage System provides dependable long-term cryogenic storage using liquid nitrogen, making it an excellent solution for stem cells, cell therapies, reproductive samples, tissue specimens, and other valuable biological materials requiring storage between -150°C and -196°C.
With an impressive 552-liter liquid nitrogen capacity and storage space for up to 38,500 standard 2.0 mL cryovials (depending on rack configuration), the CryoPlus 4 is designed for biotechnology companies, pharmaceutical manufacturers, hospitals, IVF laboratories, universities, cell therapy facilities, and biobanks managing large cryogenic repositories. Automatic liquid nitrogen filling, intelligent monitoring, and comprehensive alarm systems help protect valuable samples while reducing the day-to-day maintenance associated with manual-fill storage systems.
Many laboratories incorporate a cryogenic storage system like the CryoPlus 4 alongside biosafety cabinets for sterile sample preparation, controlled-rate freezers for optimized freezing protocols, ultra-low freezers for intermediate storage, and laboratory refrigerators for short-term reagent storage to create a complete cryopreservation workflow.
Thermo Forma CryoPlus 4 Key Features
552-liter liquid nitrogen capacity
Stores up to 38,500 standard 2.0 mL cryovials (rack dependent)
Automatic liquid nitrogen fill system
Vapor or liquid phase storage capability
Microprocessor controller with top-mounted control panel
Digital temperature display
24 tri-color LED liquid level indicators
Sixteen preset audible and visual alarm combinations
Remote alarm contacts
Temperature sleeve for improved vapor-phase performance
Stainless steel vacuum-insulated storage vessel
Heavy-duty powder-coated steel exterior
Counterbalanced insulated lid
Refurbished and performance tested by American Instrument Exchange
90-day warranty included
Thermo Forma CryoPlus 4 Overview
The CryoPlus 4 was engineered for laboratories requiring dependable long-term cryogenic preservation with minimal operator intervention. Its automatic liquid nitrogen fill system continuously maintains programmed liquid levels, eliminating the need for routine manual filling while helping ensure stable storage temperatures.
Unlike mechanical ultra-low freezers that rely on compressors, the CryoPlus 4 stores samples using liquid nitrogen, allowing laboratories to maintain storage temperatures approaching -196°C. A temperature sleeve promotes colder vapor temperatures near the top of the vessel for efficient vapor-phase storage, while the vacuum-insulated stainless steel chamber minimizes liquid nitrogen consumption and improves thermal performance. The top-mounted controller provides convenient programming and continuously monitors liquid nitrogen level, temperature, and alarm status.
Common Applications
The Thermo Forma CryoPlus 4 is commonly used for storing:
Stem cells
CAR-T cell products
Induced pluripotent stem cells (iPSCs)
Cell lines
Cord blood
Bone marrow
Embryos
Oocytes
Sperm samples
Tissue specimens
DNA repositories
Clinical trial materials
Long-term biological archives
Its large storage capacity makes it particularly well suited for laboratories maintaining centralized cryogenic repositories.
Ideal Laboratory Types
The CryoPlus 4 is an excellent choice for:
Biotechnology companies
Cell and gene therapy laboratories
Pharmaceutical manufacturers
IVF laboratories
Hospitals
Universities
Biobanks
Government research laboratories
Regenerative medicine facilities
Laboratories requiring automated liquid nitrogen storage for thousands of biological samples will appreciate the system's combination of capacity, monitoring, and dependable cryogenic performance.
Why Choose a Liquid Nitrogen Storage System?
Mechanical ultra-low freezers provide excellent long-term storage for many biological materials at temperatures as low as -86°C. However, highly sensitive biological samples—including stem cells, reproductive specimens, and advanced cell therapies—often benefit from storage at liquid nitrogen temperatures approaching -196°C.
The CryoPlus 4 provides those cryogenic temperatures while adding automatic filling, electronic monitoring, and comprehensive alarm protection to simplify laboratory operation and improve sample security.
Typical Stored Materials
The CryoPlus 4 is commonly used to preserve stem cells, CAR-T therapies, embryos, oocytes, sperm samples, cord blood, bone marrow, tissue specimens, DNA libraries, and other biological materials requiring long-term cryogenic preservation.
Thermo Forma CryoPlus 4 Key Specifications
Liquid Nitrogen Capacity
552 liters
Sample Capacity
Up to 38,500 standard 2.0 mL cryovials (configuration dependent)
Storage Temperature
Liquid nitrogen storage
Vapor or liquid phase operation
Approximately -150°C to -196°C, depending on operating mode
Construction
Vacuum-insulated stainless steel storage vessel
Heavy-duty powder-coated steel exterior
Counterbalanced insulated lid
Monitoring & Controls
Microprocessor controller
Digital temperature display
24 tri-color LED level indicators
Sixteen programmable alarm combinations
Remote alarm contacts
Automatic fill system
Electrical Requirements
100–120V or 200–230V, depending on model configuration
Exterior Dimensions
Approximately 41" H × 39" diameter
Weight
Approximately 500 lbs. empty
Operating Costs & Energy Considerations
Unlike compressor-based ultra-low freezers, the CryoPlus 4 uses liquid nitrogen as its cooling source. Operating costs are therefore driven primarily by liquid nitrogen consumption rather than electrical energy. The vacuum-insulated vessel, insulated lid, and automatic level control help reduce evaporation while maintaining dependable cryogenic temperatures. Laboratories should also consider liquid nitrogen delivery schedules and backup supply planning when implementing large cryogenic storage systems.
Specifications compiled from Thermo Scientific manufacturer literature and American Instrument Exchange product information.
Refurbishment & Testing Process
Every Thermo Forma CryoPlus 4 received by American Instrument Exchange undergoes a comprehensive inspection before shipment. Our technicians verify controller functionality, automatic fill operation, alarm systems, liquid level monitoring, lid operation, vacuum vessel integrity, electronic controls, and overall cabinet condition before thoroughly cleaning the unit for delivery.
The CryoPlus 4 ships by freight from American Instrument Exchange. Before installation, laboratories should verify doorway clearances, floor loading capacity, electrical service, liquid nitrogen supply availability, and adequate ventilation. Facilities should also establish procedures for liquid nitrogen delivery, monitoring, and emergency response before placing the system into service.
Frequently Asked Questions
How many samples can the CryoPlus 4 hold?
Depending on the rack configuration, the CryoPlus 4 can store up to 38,500 standard 2.0 mL cryovials, making it suitable for large institutional repositories and biobanks.
Can the CryoPlus 4 operate in vapor phase?
Yes. The system supports both liquid and vapor phase storage, and its integrated temperature sleeve improves temperature uniformity during vapor-phase operation.
Why choose an automatic-fill cryogenic storage system?
Automatic filling reduces manual maintenance, maintains consistent liquid nitrogen levels, improves sample protection, and provides electronic monitoring and alarm capabilities that are not available with traditional manual-fill dewars.
How is the CryoPlus 4 tested before shipment?
Every refurbished Thermo Forma CryoPlus 4 is inspected and tested by American Instrument Exchange technicians to verify controller operation, automatic fill functionality, alarm systems, liquid level monitoring, and overall system performance before shipment.
Click Hereto see the Thermo CryoPlus 4 on the American Instrument Exchange YouTube channel.
Click Hereto read a review of this product on our blog!
Testing Procedures for Used and Refurbished Laboratory Freezers
Cold Storage Reliability from American Instrument Exchange
At American Instrument Exchange, every used and refurbished laboratory freezer we offer undergoes a comprehensive multi-point testing protocol to ensure optimal performance, temperature stability, and long-term reliability. Our rigorous testing procedures are designed to meet the demanding standards of biomedical, pharmaceutical, research, and clinical environments—so you can trust your freezer to protect your valuable samples and materials.
Why Testing Refurbished Laboratory Freezers Is Critical
Before any laboratory freezer is placed back into service, it must be carefully tested for:
Consistent temperature control and uniformity across internal zones
Compressor functionality and refrigeration system performance
Seal integrity and insulation efficiency to prevent temperature loss
Electrical safety and alarm system operation
Thorough testing minimizes the risk of temperature excursions, equipment failure, and product loss—especially for temperature-sensitive items like reagents, biological samples, and vaccines.
Our structured testing protocol ensures that all used and refurbished laboratory freezers meet or exceed manufacturer specifications and industry expectations.
Key Testing Procedures for Laboratory Freezers
1. Visual and Structural Inspection
Examine the exterior for dents, corrosion, or physical damage
Check door gaskets, hinges, and latches for wear and functionality
Inspect power cords, control panels, and internal compartments
2. Functional Startup and System Check
Power on the unit to verify startup sequence, control panel functionality, and display readability
Test programmable settings, alarms, and door-open sensors
Ensure proper door closure and sealing performance
3. Temperature Performance and Stability Testing
Test temperature sensors using certified thermometers or probes
Monitor chamber temperature at multiple points over extended run periods
Verify temperature uniformity and accuracy across common lab setpoints (e.g., -20°C, -30°C)
4. Compressor and Refrigeration System Evaluation
Test compressor startup, cycling behavior, and operating noise
Check condenser coils, evaporators, and fans for performance and cleanliness
Inspect for refrigerant leaks or pressure issues that may affect efficiency
5. Electrical Safety and Compliance Verification
Confirm proper grounding and insulation of all electrical components
Conduct safety testing to meet laboratory equipment electrical standards
Verify functionality of alarms for power loss, temperature excursions, and system faults
6. Final Quality Assurance and Runtime Validation
Conduct multi-day test cycle to confirm stable performance under continuous use
Record temperature data, alarm responses, and compressor cycling metrics
Complete final inspection and prepare detailed service documentation
Reliable Cold Storage, Backed by Testing Excellence
Each refurbished laboratory freezer from American Instrument Exchange is tested and certified for cold storage accuracy, safety, and performance. Whether upright, undercounter, flammable-material rated, or specialty-purpose, our lab freezers are restored to meet real-world research and clinical demands.
Trust American Instrument Exchange for dependable, tested, and warrantied laboratory refrigeration—ready to support your lab from day one.
Repair and Refurbishment Protocol for Used Laboratory Freezers Certified Cold Storage Performance from American Instrument Exchange
At American Instrument Exchange, every used laboratory freezer we offer is subjected to a comprehensive repair and refurbishment protocol. Whether it’s a general-purpose lab freezer, flammable-material grade unit, or undercounter model, our goal is to restore each system to peak performance—ensuring consistent temperature control and reliable operation.
Why Choose a Refurbished Laboratory Freezer from American Instrument Exchange?
• Fully tested for cold storage accuracy and operational safety
• Backed by a warranty
• Cost-effective alternative to new refrigeration equipment
• Sustainably refurbished to reduce environmental impact
• Serviced by expert technicians with decades of laboratory equipment experience
Step-by-Step Refurbishment Protocol
Every laboratory freezer from American Instrument Exchange follows a detailed, multi-stage process to ensure top-tier performance and reliability:
1. Initial Intake & Inspection
• Visual inspection for dents, corrosion, or structural damage
• Mechanical check of door hinges, gaskets, seals, and internal components
• Documentation of missing parts or areas requiring repair or replacement
2. Cleaning and Decontamination
• Internal and external cleaning using non-abrasive cleaners
• Decontamination/cleaning of all surfaces to remove biological or chemical residues
• Thorough cleaning of shelving, drawers, and removable interior parts
3. Mechanical and Electrical Repairs
• Replacement or repair of worn mechanical parts (door latches, seals, hinges, etc.)
• Inspection and restoration of control interfaces, thermostats, sensors, and displays
• Evaluation of wiring, relays, fuses, and power supply components for safety and integrity
4. Refrigeration System and Compressor Evaluation
• Testing of compressor function, condenser coils, and evaporators
• Inspection for refrigerant leaks and pressure performance (if applicable)
• Verification of proper airflow, fan operation, and defrost cycles
5. Temperature Calibration and Performance Testing
• Testing of temperature sensors and control boards
• Verification of temperature stability and uniformity throughout the chamber
• Testing of multiple setpoints (e.g., -20°C to -30°C) over extended operating periods
6. Safety and Compliance Checks
• Inspection of grounding and electrical insulation per lab safety standards
• Testing of alarm systems (if applicable) for temperature excursions or power failure
7. Final Quality Control and Documentation
• Multi-day operational test
• Final cleaning, inspection, and performance validation
• Detailed service report with temperature logs and repair notes
Trust the Experts at American Instrument Exchange
With over 50 years of industry experience, American Instrument Exchange is a leading provider of high-quality refurbished laboratory equipment. Our proven laboratory refrigerator refurbishment protocol ensures consistent, accurate cold storage—so you can safeguard your samples with confidence.
Warranty Information
All used equipment sold by American Instrument Exchange is refurbished/reconditioned, tested to meet specifications, cleaned, and comes with a 90-day warranty from the date of shipment unless otherwise specified. New products include a warranty from the manufacturer. Your warranty is only valid if you have paid your invoice. If your invoice is over 30 days old, warranty work will not be performed until your invoice is paid in full. American Instrument Exchange is not liable for any special or consequential damages that result from the use of, or the inability to use, the materials on this site or the performance of the products,
Exceptions include international sales and items that are agreed to be sold with a lesser warranty or items that are agreed to be sold “as is.”
Should there be visible shipping damage to packaging or concealed shipping damage to item(s) supplied, buyer must communicate such damage to the delivering entity or carrier upon receipt first and to American Instrument the same day item is accepted / signed for. Failure to do so voids warranty. Customer decision to involve / procure third party or OEM service other than American Instrument or AIE assigned vendors to resolve in-warranty instrument failure or defect without first placing a service call to American Instrument voids warranty.
Return & Cancellation Policy
American Instrument Exchange will authorize the return of and issue a full refund for any equipment that is not working as represented and could not be replaced or repaired to the customer’s satisfaction by AIE or a representative of AIE during the warranty period. Returns without prior authorization and an RMA number will not be accepted.
Customers are responsible for proper packaging of the equipment and all included accessories. American Instrument will pay for insurance and shipping costs. Non-inventory items bought specifically to fill customer orders may possibly be returned, but on a case by case basis.
Customers who cancel orders after refurbishing has begun or after delivery where there are no equipment performance issues may be subject to a Restocking/Cancellation Fee of 20% or more and responsible for shipping costs for both the delivery and return.
Ongoing and Extended Support Options
American Instrument Exchange is able to provide additional repair and support services outside the warranty terms for most products that sell.
For biosafety cabinets, clean benches, chemical fume hoods, and other clean air products our team at AIE Laboratory Services can provide certifications, repairs, decontaminations, and other services for customers throughout New England, and guidance and limited technical assistance for any customers in the US and Canada for new or refurbished biosafety cabinets purchased from American Instrument Exchange.
For all other products, the repair service team at American Instrument Exchange can provide both field and depot repair evaluations. We can easily schedule and coordinate the pick-up and transportation of your malfunctioning equipment. By offering hourly rates lower than most OEM service providers and eliminating travel time for technicians, we help reduce repair costs. Furthermore, our lab depot repair service minimizes or eliminates scheduling delays. Our experienced service technicians are qualified to restore your equipment to factory specifications.
Yes, all equipment from American Instrument Exchange comes with a warranty. Used/reconditioned/refurbished equipment is tested to make sure it operates to the manufacturer's specifications and comes with a 90-day warranty (unless otherwise noted). New equipment comes with a warranty from the manufacturer.
How do you test and recondition the equipment?
Testing requirements vary across all the equipment categories we sell. Temperature controlled units are tested with NIST traceable probes and data loggers. Gaskets, external housing, glass, handles, controls and control screens are all thoroughly inspected for integrity and functionality. We test all equipment using the manufacturer's parameters and specifications to confirm that the unit operates properly.
How do products ship from American Instrument Exchange?
We can ship products both nationally and internationally using a well-established network of transporters. Smaller items will ship via UPS. Larger equipment will be palletized and shipped either LTL or air-ride, depending on the specific equipment and/or delivery requirements.
Return and order cancellation policy
American Instrument Exchange will accept the return of any product that is not working as represented and could not be replaced or repaired to the customer's satisfaction during the warranty period. Customers who cancel orders after refurbishing has begun will be subject to a cancellation and restocking fee of between 20% and 40%.
Are discounts available for educational or non-profit institutions, or for bulk purchases?
Yes – call or email us today with a list of equipment you're looking for and we can potentially put together a quote that includes a discount.
How does your price matching policy work?
We strive to keep our pricing competitive and reasonable. If you find comparable items for sale at a lower price from other vendors please send us a link and or quote for the item and we'll do our best to match or beat the price.
Can I see the equipment in person before committing to a purchase?
Customers are welcome to make an appointment to view equipment in our warehouse. Given our workload we may not be able to test or clean the equipment prior to your arrival if you have not committed to an order.
1023 Western Avenue is a working warehouse, not a showroom, and customers should dress appropriately and wear closed toe shoes.
Can I ship products that I purchased elsewhere to American Instrument for repair?
Yes – please see our repair services page for more information.
