Thermo MegaFuge ST4R Plus-MD

Brand : Thermo

Product Code : SKU 1397HH CENTRI

$10,500.00

Price Match Policy

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Thermo Scientific Megafuge ST4R Plus-MD Refrigerated Benchtop Centrifuge (Rotor Not Included) - Refurbished

The Thermo Scientific Megafuge ST4R Plus-MD is a refrigerated benchtop centrifuge designed for clinical laboratories, biotechnology workflows, pharmaceutical environments, molecular biology applications, blood processing workflows, and general laboratory sample preparation. This particular configuration is sold without a rotor, allowing laboratories to configure the system with the specific Thermo Scientific rotor platform best suited to their workflow requirements. The Megafuge ST4R Plus-MD supports a broad range of fixed-angle and swinging bucket rotor options, making it one of the most versatile refrigerated benchtop centrifuge platforms available for routine and high-throughput laboratory applications.

Laboratories evaluating refrigerated benchtop centrifuges often compare refrigeration stability, rotor flexibility, throughput capability, maximum RPM and RCF performance, and workflow versatility when selecting a centrifuge system. The Thermo Scientific Megafuge ST4R Plus-MD is engineered specifically for laboratories requiring reliable refrigerated centrifugation across multiple applications while maintaining a compact footprint and simplified operation. Because this system is sold without a rotor, customers can select the rotor configuration that best matches their clinical, molecular biology, blood processing, or biotechnology workflow requirements.

At American Instrument Exchange, our technicians inspect and test each centrifuge to verify proper refrigeration performance, motor operation, braking systems, lid lock functionality, and controller operation prior to shipment. American Instrument Exchange offers used and refurbished laboratory centrifuges for sale, including refrigerated centrifuges, floor model centrifuges, benchtop centrifuges, and large-capacity bioprocessing centrifuge systems from leading manufacturers including Thermo Scientific, Beckman Coulter, Eppendorf, and more.

Features of the Thermo Scientific Megafuge ST4R Plus-MD

Refrigerated benchtop centrifuge
Rotor not included
Supports 13 Thermo Scientific rotor configurations
Maximum speed up to 15,200 RPM depending on rotor
Maximum force up to 25,830 x g depending on rotor
Refrigerated chamber for temperature-sensitive workflows
Temperature range from -10°C to +40°C
Auto-Lock III rotor exchange system
SMARTSpin rotor management technology
High-capacity processing capability up to 4 liters
Touch-button control interface with LCD display
Supports blood tubes, conical tubes, bottles, microplates, and bioprocessing workflows
Compact laboratory footprint
Clinical and research laboratory compatibility
90-day warranty included from American Instrument Exchange
Refurbished and tested by American Instrument Exchange

The Thermo Scientific Megafuge ST4R Plus-MD is designed to provide flexible refrigerated centrifugation while allowing laboratories to customize rotor configurations for specific workflow requirements.

Overview of the Thermo Scientific Megafuge ST4R Plus-MD Refrigerated Centrifuge

The Thermo Scientific Megafuge ST4R Plus-MD is a refrigerated benchtop centrifuge optimized for clinical diagnostics, blood processing, molecular biology workflows, pharmaceutical sample preparation, microbiology applications, biotechnology research, and general laboratory centrifugation procedures. Unlike fixed-configuration centrifuges that are optimized for only one workflow type, the Megafuge ST4R Plus-MD platform is designed around interchangeable rotor systems that allow laboratories to adapt the centrifuge to changing workflow requirements.

The refrigerated chamber helps maintain stable sample temperatures during centrifugation, making the system particularly valuable for temperature-sensitive biologic samples, pharmaceutical workflows, molecular biology applications, and clinical laboratory processing. Thermo Scientific's Auto-Lock III rotor exchange system allows users to change rotors without tools, reducing downtime and simplifying workflow transitions between blood tube processing, bottle centrifugation, conical tube applications, and microplate workflows.

The combination of refrigeration performance, flexible rotor support, high-capacity processing capability, and compact benchtop design makes the Megafuge ST4R Plus-MD especially valuable in hospitals, biotechnology facilities, pharmaceutical laboratories, academic research environments, and clinical laboratory settings.

Browse additional used centrifuges for sale from American Instrument Exchange.

Common Applications for the Thermo Scientific Megafuge ST4R Plus-MD

The Thermo Scientific Megafuge ST4R Plus-MD is commonly used for blood and plasma separation, clinical diagnostics, molecular biology workflows, pharmaceutical sample preparation, microbiology applications, biotechnology research, protein purification, cell culture harvesting, conical tube processing, microplate centrifugation, and general laboratory centrifugation procedures. The refrigerated chamber helps maintain stable sample temperatures during centrifugation, making the system especially valuable for temperature-sensitive clinical and biologic applications where preserving sample integrity is critical. Because the system is sold without a rotor, laboratories can configure the centrifuge specifically for their workflow requirements using compatible Thermo Scientific rotor platforms.

Rotor Compatibility and Rotor Availability

Rotor flexibility is one of the primary advantages of the Thermo Scientific Megafuge ST4R Plus-MD platform. This centrifuge is sold without a rotor, allowing laboratories to select the rotor configuration best suited to their applications.

Compatible rotor options may include:

TX-1000 swinging bucket rotor
TX-750 swinging bucket rotor
BIOShield 1000A rotor
BIOShield 720 rotor
Fixed-angle rotor configurations
Blood tube processing rotors
Conical tube processing rotors
Microplate rotor configurations
Bottle processing rotors

Depending on rotor selection, the Megafuge ST4R Plus-MD can support:

Blood tube processing
Conical tube workflows
Cell culture harvesting
Microplate centrifugation
Bottle processing applications
Clinical diagnostics workflows
Molecular biology applications
Biotechnology sample preparation

The Thermo Scientific Auto-Lock III rotor exchange system allows rapid rotor changes without tools, making the Megafuge ST4R Plus-MD especially useful in multi-user laboratory environments.

Customers should verify rotor availability and compatibility prior to purchase, as rotor inventory can vary.

Specifications for the Thermo Scientific Megafuge ST4R Plus-MD

Specification	Details
Manufacturer	Thermo Scientific
Model	Megafuge ST4R Plus-MD
Centrifuge Type	Refrigerated Benchtop Centrifuge
Included Rotor	None
Maximum Capacity	Up to 4 x 1000 mL (depending on rotor)
Maximum Speed	Up to 15,200 RPM
Maximum RCF	Up to 25,830 x g
Temperature Range	-10°C to +40°C
Refrigeration Type	Compressor-Based Refrigeration
Rotor Exchange System	Auto-Lock III
Control Interface	LCD Push-Button Display
Electrical Requirements	120V, 50/60Hz
Dimensions	Approx. 27.2" L x 29.4" W x 14.2" H
Weight	Approx. 120 kg (265 lbs)

Specifications are provided to assist with planning and installation. Rotor compatibility, included accessories, and system configuration may vary depending on the specific unit available for sale.

Power Requirements and Shipping Considerations

The Thermo Scientific Megafuge ST4R Plus-MD typically requires 120V, 50/60Hz electrical service and is designed for benchtop laboratory installation. Laboratories should verify electrical compatibility, available bench space, and ventilation requirements prior to purchasing this centrifuge.

Although the Megafuge ST4R Plus-MD is a benchtop centrifuge, the system weighs approximately 265 pounds and contains refrigeration components that require protective packaging during transport. Most systems ship via palletized freight carrier to protect sensitive refrigeration and control components during delivery.

American Instrument Exchange can assist customers with freight coordination, shipping preparation, and installation planning for refrigerated laboratory centrifuges.

Refurbished Centrifuges from American Instrument Exchange

American Instrument Exchange specializes in refurbished laboratory centrifuges including refrigerated centrifuges, floor model centrifuges, benchtop centrifuges, blood banking centrifuges, and bioprocessing centrifuge systems.

Our technicians inspect and test centrifuges for:

Refrigeration performance
Rotor operation (when applicable)
Brake functionality
Controller operation
Lid lock safety systems
General operational reliability

If the centrifuge is sold with a rotor, we also test the rotor and centrifuge combination together to verify compatibility and operational performance.

Browse additional used centrifuges for sale, laboratory freezers and ultralow freezers, laboratory incubators, and biosafety cabinets from American Instrument Exchange.

Service and Support for Laboratory Centrifuges

American Instrument Exchange and AIE Laboratory Services provide centrifuge repair, preventive maintenance, diagnostics, and laboratory equipment service for many Thermo Scientific centrifuge models.

Available services may include:

Refrigeration system service
Centrifuge diagnostics
Rotor inspection
Preventive maintenance
Controller troubleshooting
Calibration support
General laboratory equipment repair

In addition to centrifuges, we also service laboratory freezers and ultralow freezers, biosafety cabinets, incubators, laboratory refrigerators, cryostats, freeze dryers, and other laboratory equipment.

Thermo Scientific Megafuge ST4R Plus-MD Refrigerated Benchtop Centrifuge Frequently Asked Questions

Does this Thermo Scientific Megafuge ST4R Plus-MD include a rotor?

No. This particular Megafuge ST4R Plus-MD is being sold without a rotor, allowing laboratories to select the rotor configuration that best matches their workflow requirements.

What rotors are compatible with the Thermo Scientific Megafuge ST4R Plus-MD?

The Megafuge ST4R Plus-MD supports numerous Thermo Scientific rotor configurations including TX-1000, TX-750, BIOShield, fixed-angle, blood tube, bottle processing, and microplate rotor systems.

What is the Thermo Scientific Megafuge ST4R Plus-MD used for?

The Megafuge ST4R Plus-MD is commonly used for clinical diagnostics, blood processing, biotechnology workflows, pharmaceutical sample preparation, molecular biology applications, and general laboratory centrifugation procedures.

Is the Thermo Scientific Megafuge ST4R Plus-MD refrigerated?

Yes. The Megafuge ST4R Plus-MD is a refrigerated benchtop centrifuge with a temperature range of approximately -10°C to +40°C.

What is the maximum capacity of the Megafuge ST4R Plus-MD?

Depending on rotor configuration, the system can support capacities up to 4 x 1000 mL.

Does the Megafuge ST4R Plus-MD support blood tube processing?

Yes. With the appropriate rotor and adapters, the system can process up to 196 blood tubes and is commonly used in clinical laboratory environments.

What is Thermo Scientific Auto-Lock III technology?

Auto-Lock III is a tool-free rotor exchange system that allows users to quickly change rotors without additional tools, reducing downtime and improving workflow flexibility.

Can American Instrument Exchange help source a compatible rotor?

Yes. American Instrument Exchange frequently stocks compatible Thermo Scientific rotors and can help identify rotor options for blood processing, conical tube workflows, bottle processing, microplate centrifugation, and other laboratory applications.

What industries commonly use the Megafuge ST4R Plus?

This centrifuge is widely used in clinical and hospital laboratories, biotechnology and pharmaceutical labs, academic research institutions, environmental and industrial testing labs, and any other labs looking for a dependable high-throughput refrigerated centrifuge. Its versatility makes it a go-to general-purpose centrifuge platform.

What are the most common laboratory applications for the Thermo Scientific Megafuge ST4R Plus?

The Thermo Scientific Megafuge ST4R Plus is designed as a versatile, general-purpose centrifuge that supports a wide range of routine and specialized laboratory workflows. Its high capacity, rotor flexibility, and refrigeration make it suitable for applications such as:

· Clinical diagnostics: Separation of whole blood into plasma or serum, processing of urine samples, and preparation of clinical specimens

· Cell culture workflows: Harvesting cells, pelleting bacteria or yeast, and clarifying cell lysates

· Molecular biology: DNA/RNA extraction, PCR sample prep, and nucleic acid purification

· Biochemistry and proteomics: Protein isolation, enzyme preparation, and sample fractionation

· Pharmaceutical and biotech research: Drug development workflows, sample clarification, and quality control testing

· Environmental and industrial labs: Processing water samples, particulates, and chemical suspensions

Thanks to its temperature control (-10°C to +40°C) and compatibility with both high-speed fixed-angle and large-capacity swinging-bucket rotors, the Megafuge ST4R Plus can handle everything from temperature-sensitive biomolecules to high-throughput clinical batches—making it an ideal all-in-one centrifuge for busy labs.

What types of rotors and tubes are compatible?

The Megafuge ST4R Plus supports over a dozen rotor options, including:

· Swinging-bucket rotors (e.g., TX-1000 for large volumes)

· Fixed-angle rotors for high-speed micro applications

· Specialized rotors for blood tubes, conical tubes, microplates, and syringes

It can process up to 76 blood tubes per run and up to 16 x 50 mL conical tubes, making it a great option for labs looking for larger capacity centrifuges without dedicating the funds or floor space to a floor model unit like the Thermo Lynx 6000.

How easy is it the Thermo Megafuge ST4R to operate?

This centrifuge is designed for intuitive, routine use:

· Simple push-button interface with LCD display

· Stores up to 6 programmable runs

· Auto-Lock rotor system enables tool-free rotor changes

· Motorized lid latch for easy one-handed operation

These features reduce training time and improve lab efficiency.

Is a used or refurbished Megafuge ST4R Plus reliable?

Yes—when purchased from a trusted supplier like American Instrument Exchange, refurbished units are fully tested and inspected, professionally cleaned and calibrated, and verified for performance and safety. Because Thermo Scientific centrifuges are built for durability, refurbished systems can deliver years of reliable service at a significantly lower cost.

What are the advantages of buying a refurbished centrifuge?

Purchasing a refurbished Megafuge ST4R Plus offers:

· Significant cost savings vs. new units

· Faster availability compared to factory lead times

· Sustainable reuse of high-quality lab equipment

· Access to premium features at a reduced budget

This makes it ideal for growing labs, startups, and budget-conscious facilities. You can read more about the advantages of buying refurbished equipment on our blog.

Testing Procedures for Used and Refurbished Laboratory Centrifuges

Ensure Quality, Accuracy, and Compliance Before Deployment

Used and refurbished laboratory centrifuges from American Instrument Exchange undergo testing procedures to ensure they meet the performance, safety, and compliance standards required in modern laboratories.

Why Testing Used Laboratory Centrifuges Is Essential

Before a centrifuge is reintroduced into a lab environment, it must be tested for:

Mechanical integrity
Rotor balance and speed accuracy
Safety system functionality
Electrical compliance

Proper testing helps extend equipment lifespan, reduce downtime, and ensure safety in high-stakes lab environments such as clinical diagnostics, biotechnology, and research applications.

Our structured testing protocol for used and refurbished centrifuges ensures equipment safety, accuracy, and longevity.

Key Testing Procedures for Refurbished and Used Centrifuges

1. Initial Visual Inspection

Check for signs of wear, corrosion, or damage to housing, lid, and control panels
Inspect power cords, plugs, and connectors for fraying or exposed wiring
Confirm that the rotor and accessories are compatible and undamaged

2. Functional Testing

Power up the centrifuge and confirm successful boot-up of digital or analog displays
Test lid lock and emergency stop mechanisms
Run initial cycles at various speeds to check for abnormal noise or vibration

3. Rotor and Speed Verification

Test all programmable speed settings to confirm consistent acceleration and deceleration
Monitor temperature, vibration, and RPM consistency throughout the cycle
Balance testing ensures smooth operation and prevents wear on internal components

4. Electrical Safety and Grounding Tests

Verify that all electrical components are properly grounded and shielded

5. Temperature Control (if applicable)

For refrigerated centrifuges, test cooling function to ensure temperature stability within set ranges
Check refrigerant levels and inspect for compressor noise or failure

6. Final Quality Assurance Checklist

Conduct a full run-through using the user interface
Document all test results

Repair and Refurbishment Protocol for Used Laboratory Centrifuges

Certified Quality from American Instrument Exchange

At American Instrument Exchange, we follow a meticulous repair and refurbishment protocol to ensure that every used laboratory centrifuge we sell. We strive for reliable performance and long-term durability—providing labs with exceptional value on high-quality pre-owned centrifuges.

Why Choose a Refurbished Centrifuge from American Instrument Exchange?

Fully tested
Backed by warranty and performance guarantee
Cost-effective alternative to new lab equipment
Environmentally responsible through equipment reuse
Supported by expert technicians with decades of experience

Step-by-Step Refurbishment Protocol

Every used centrifuge at American Instrument Exchange goes through the following comprehensive repair and refurbishment process:

1. Initial Intake & Inspection

Our technicians perform a complete visual and mechanical inspection
Evaluation of hinges, seals, gaskets, and electrical components
Any physical damage, missing parts, or wear is documented for repair

2. Cleaning and decontamination

Full internal and external cleaning using non-abrasive, disinfectant-safe products
Biological or chemical residue is decontaminated/cleaned

3. Mechanical & Electrical Repairs

Damaged or worn parts (e.g., drive motors, lid latches, rotor buckets) are replaced or repaired
Electrical components, sensors, and fuses are tested and replaced as needed
Wiring is inspected for integrity and safety per industry standards

4. Rotor & Accessory Evaluation

All rotors, buckets, and adapters are inspected for cracks, corrosion, and balance
Non-conforming components are replaced with OEM or equivalent alternatives

5. Performance Testing

Rotor speed (RPM), acceleration, and deceleration are verified
Refrigerated centrifuges undergo temperature stability testing across set ranges

6. Safety System Verification

Lid lock and interlock systems are tested for proper function
Emergency stop and imbalance detection systems are verified
Electrical safety and grounding tests are conducted

Trust the Experts at American Instrument Exchange

With over 50 years of experience in the industry, American Instrument Exchange is a trusted name for refurbished lab equipment. Our centrifuge refurbishment protocol reflects our commitment to quality, safety, and customer satisfaction.

Warranty Information

All used equipment sold by American Instrument Exchange is refurbished/reconditioned, tested to meet specifications, cleaned, and comes with a 90-day warranty from the date of shipment unless otherwise specified. New products include a warranty from the manufacturer. Your warranty is only valid if you have paid your invoice. If your invoice is over 30 days old, warranty work will not be performed until your invoice is paid in full. American Instrument Exchange is not liable for any special or consequential damages that result from the use of, or the inability to use, the materials on this site or the performance of the products,

Exceptions include international sales and items that are agreed to be sold with a lesser warranty or items that are agreed to be sold “as is.”

Should there be visible shipping damage to packaging or concealed shipping damage to item(s) supplied, buyer must communicate such damage to the delivering entity or carrier upon receipt first and to American Instrument the same day item is accepted / signed for. Failure to do so voids warranty. Customer decision to involve / procure third party or OEM service other than American Instrument or AIE assigned vendors to resolve in-warranty instrument failure or defect without first placing a service call to American Instrument voids warranty.

Return & Cancellation Policy

American Instrument Exchange will authorize the return of and issue a full refund for any equipment that is not working as represented and could not be replaced or repaired to the customer’s satisfaction by AIE or a representative of AIE during the warranty period. Returns without prior authorization and an RMA number will not be accepted.

Customers are responsible for proper packaging of the equipment and all included accessories. American Instrument will pay for insurance and shipping costs. Non-inventory items bought specifically to fill customer orders may possibly be returned, but on a case by case basis.

Customers who cancel orders after refurbishing has begun or after delivery where there are no equipment performance issues may be subject to a Restocking/Cancellation Fee of 20% or more and responsible for shipping costs for both the delivery and return.

Ongoing and Extended Support Options

American Instrument Exchange is able to provide additional repair and support services outside the warranty terms for most products that sell.

For biosafety cabinets, clean benches, chemical fume hoods, and other clean air products our team at AIE Laboratory Services can provide certifications, repairs, decontaminations, and other services for customers throughout New England, and guidance and limited technical assistance for any customers in the US and Canada for new or refurbished biosafety cabinets purchased from American Instrument Exchange.

For all other products, the repair service team at American Instrument Exchange can provide both field and depot repair evaluations. We can easily schedule and coordinate the pick-up and transportation of your malfunctioning equipment. By offering hourly rates lower than most OEM service providers and eliminating travel time for technicians, we help reduce repair costs. Furthermore, our lab depot repair service minimizes or eliminates scheduling delays. Our experienced service technicians are qualified to restore your equipment to factory specifications.

Please contact our team at info@americaninstrument.com for more details.

FAQ

Does the equipment come with a warranty?

Yes, all equipment from American Instrument Exchange comes with a warranty.
Used/reconditioned/refurbished equipment is tested to make sure it operates to the manufacturer's specifications and comes with a 90-day warranty (unless otherwise noted). New equipment comes with a warranty from the manufacturer.

How do you test and recondition the equipment?

Testing requirements vary across all the equipment categories we sell. Temperature controlled units are tested with NIST traceable probes and data loggers. Gaskets, external housing, glass, handles, controls and control screens are all thoroughly inspected for integrity and functionality.
We test all equipment using the manufacturer's parameters and specifications to confirm that the unit operates properly.

How do products ship from American Instrument Exchange?

We can ship products both nationally and internationally using a well-established network of transporters. Smaller items will ship via UPS. Larger equipment will be palletized and shipped either LTL or air-ride, depending on the specific equipment and/or delivery requirements.

Return and order cancellation policy

American Instrument Exchange will accept the return of any product that is not working as represented and could not be replaced or repaired to the customer's satisfaction during the warranty period. Customers who cancel orders after refurbishing has begun will be subject to a cancellation and restocking fee of between 20% and 40%.

Are discounts available for educational or non-profit institutions, or for bulk purchases?

Yes – call or email us today with a list of equipment you're looking for and we can potentially put together a quote that includes a discount.

How does your price matching policy work?

We strive to keep our pricing competitive and reasonable. If you find comparable items for sale at a lower price from other vendors please send us a link and or quote for the item and we'll do our best to match or beat the price.

Can I see the equipment in person before committing to a purchase?

Customers are welcome to make an appointment to view equipment in our warehouse. Given our workload we may not be able to test or clean the equipment prior to your arrival if you have not committed to an order.

1023 Western Avenue is a working warehouse, not a showroom, and customers should dress appropriately and wear closed toe shoes.

Can I ship products that I purchased elsewhere to American Instrument for repair?

Yes – please see our repair services page for more information.